Research

Regenerating and modelling tissues

We develop new approaches to repair or replace diseased and damaged tissue of the human body. We combine approaches from diverse interdisciplinary fields of research. This spans biomaterials, engineering, nanotechnology, stem cell technology and the emerging field of electroceutics, which seeks to modulate bio-electricity as a novel treatment.

Our discovery and applied research seeks to understand and control the cellular and molecular processes underlying various human diseases for therapeutic benefit. We create materials that respond to stimuli and self-assemble into micro-structures, which influence cell behaviour.

We also guide stem cell differentiation into defined phenotypes. Combining these biomaterials and cells provides in vitro models to understand disease process, hence develop approaches to restore tissue function that has been lost through damage or disease.

Project examples include:

  • Bioelectronics for modulating and sensing bio-electricity
  • Advanced stem cell-derived technology and gene editing to model human diseases for discovery research and drug development
  • Non-viral delivery of DNA, mRNA and proteins for tissue regeneration
  • Precision assembly of complex cellular 3D micro-environments with optical tweezers and bio-printing
  • Biologically derived wraps for nerve and tendon regeneration (MRC DPFS)

Theme Leads: Mattéa Finelli and Nick Hannan

Research highlights

  • Cathy Merry. BBSRC sLOLA; £4.4M; GlycoWeb is on regulation and function of glycosaminoglycans (GAGs) using advanced non-animal methodologies
  • Felicity Rose. EPSRC Research & Partnership Hubs for Health; £14M; MAINSTREAM - Manufacturing Stem Cells for Regenerative Medicine, Immunotherapy and Cancer
  • Felicity Rose. EPSRC; £7.2M; Dialling up performance for on demand manufacturing
  • Felicity Rose. InnovateUK; £240K; BIOdegradable electroSPINning manufactured FILters for housed livestock farm pollution capture
  • Karen Robinson. MRC; £3.5M; Advanced Interdisciplinary Models Doctoral Training Partnership mid-term renewal
  • Laura Sidney. MRC IAA; £73,934; Human transplant potential of donated corneas preserved by low-temperature vacuum evaporation
  • Lisa White. The Steve Morgan Grand Challenge; £3M; Translating GLP compatible immuno-modulatory and pro-regenerative particles to promote the function of islets following transplantation in humans
  • Mattéa Finelli. NC3Rs; £100K; Towards a clinical-trial-in-a-dish: Validating an animal product-free stem cell-derived 3D model of Alzheimer’s disease for drug discovery
  • Victoria James. BHF; £1M; Do snoRNAs govern genotype-phenotype interactions in hypertrophic cardiomyopathy?

Our researchers

Search the table below to find out more about our researchers. You are able to filter the table by searching for names, keywords, and techniques.

 
Full list of our researchers
NameResearch keywordsResearch techniques
Cinzia Allegrucci Cancer, stem cells, epigenetics, disease modelling, genetics iPSC technology, 3D cell culture models, in vitro assays, epigenetic analysis
Kenton Arkill Vascular permeability, endothelial glycocalyx, electron microscopy, correlative microscopy techniques     Functional permeability assays, 3D TEM, correlative microscopy techniques
Jennifer Ashworth Biomaterials, fibrosis, cancer research, 3D in vitro models, imaging tissue 3D cell culture, biomaterials design and fabrication, primary cell/ organoid culture, confocal imaging, micro-CT analysis
Dave Bates Angiogenesis, vascular remodelling, cholangiocarcinoma, renal glomerular physiology, diabetes In vivo imaging, RNA splicing, molecular and cellular biology, drug discovery
Andrew Benest Endothelial cells, lymphatics, angiogenesis, vasculature, transcription factors  Transcriptomic, in vivo modelling, confocal imaging
Lee Buttery 3D cell models, stem cells, osteoblasts, cell-materials interactions, tissue engineering    3D and ES cell culture, osteoblast culture, immunocytochemistry, optical tweezers for cell biology
Beth Coyle Paediatric brain tumours, resistance, metastasis, tumour microenvironment    3D cell culture, apoptosis, cytotoxicity, migration assays
Chris Denning Human pluripotent stem cells (hPSCs), heart/ cardiovascular disease, drug discovery and evaluation, regenerative medicine        Cardiovascular lineage differentiation, CRISPR engineering, phenotype-genotype correlations, automation
James Dixon Gene therapy, gene editing, vaccines, nucleic acid delivery, regenerative medicine Genetic engineering/ editing, nanoformulation, reporter assays, particle characterisation, biomaterials
Mattea Finelli Neurodegenerative diseases, redox mechanisms, oxidative and nitrosative stresses, proteomics, post-translational modifications of proteins      Quantitative/ redox/ PTMs proteomics, cell- and recombinant protein-based assays, stem cell derived disease models, various cell cultures (cortical, cerebellar, hippocampal, DRG, motor neurons)
Amanda Goodwin Fibrosis, development, lung repair In vitro cell stretch (Flexcell), G protein knockdown studies, TMLC assays (TGFbeta signalling assay), ECM crossover studies
Nicholas Hannan Stem cells, disease modelling, respiratory disease, liver disease, inflammatory bowel disease         Stem cell differentiation, cell phenotyping, gene editing, CRISPR base editing, organoids
Mohammad Ilyas Colorectal cancer, mutation analysis, liquid biopsy, cancer biomarkers, tissue modelling          Histopathology, PCR, co-culture models, gene cloning
Victoria James Extracellular vesicles, RNA biology, cancer metastasis, epigenetics, inter-cellular communication Nanoparticle biology, RNA biology, cell biology, epigenetics
Simon Johnson Tissue remodelling, proteases, extracellular matrix, rare lung disease, drug repurposing    Protease assays, complex cell culture, molecular pathology
Barrie Kellam Medicinal chemistry, fluorescent ligands, G protein-coupled receptors, drug discovery       Medicinal chemistry, molecular modelling, biospectroscopy, HPLC, fluorescence Imaging
Alvaro Mata Biomaterials, tissue engineering, regenerative materials, in vitro models, biomineralization       Self-assembly, bioprinting, electron microscopy
Cathy Merry Matrix biology, cancer research, disease modelling, glycobiology   Glycobiology, hydrogel development, stem cell culture and differentiation, matrix biology, in vitro disease models
Abhik Mukherjee Digital/ molecular pathology, gastrointestinal and pancreaticobiliary cancers, translational therapeutics, inflammatory bowel disease Histopathology and immunohistochemistry, digital pathology and image analyses, molecular pathology, functional biology
Paloma Ordóñez Morán Stem cells, inflammation, differentiation, cancer, tumour heterogeneity 3D organoids, primary mouse and human cell culture, stem cell-based approaches, in vivo assays, gene expression
Frankie Rawson Wireless bioelectronics, bioelectricity, electrochemistry, bionanotechnology, bioelectronic medicine SECM-AFM, voltammtery, amperomerty
Felicity Rose Biointerfaces; biomaterials; peptide materials; hydrogels; computational material science Surface modification and analysis; polymerisation kinetics; light and enzyme responsive materials; material characterisation
Ian Sayers Molecular, genetic and cellular mechanisms underlying asthma and chronic obstructive pulmonary disease, virus-host interactions, stratified medicine Gene discovery, primary airway cell and tissue models, functional genetics, transcriptomics, patient translational studies
Abdol Shams-Nateri Adult stem cells and cancer, precision oncology/ personalized cancer treatments, intra-tumour heterogeneity, cell signalling and transcription, ubiquitin proteasome system and F-box proteins         3D Organoids and explants models, gene targeting and transgenics, CRISPR-Cas gene editing systems, epithelial and hematopoietic stem cells assays
Amanda Tatler Respiratory disease, tissue remodelling, fibrosis, matrix, 3D models Precision cut tissue slices, in vivo respiratory models, molecular biology, TGFb activation assays, immunohistochemistry/ immunofluorescence
Alex Thompson Blood cancer, stem cell technologies, pre-clinical evaluation, next-generation models, drug discovery       In vivo modelling, iPSC maintenance and differentiation, haematopoiesis, colony-forming assays, gene expression profiling
Lisa White Regenerative medicine, biomaterials, extracellular matrix, hydrogels, microparticles Decellularization, micro x-ray computed tomography, mammalian cell culture, biomaterials characterisation, supercritical CO2
Jing Yang Biomaterials, 3D bioprinting, tissue engineering, regenerative medicine, immunomodulatory materials 3D printing, biomaterial preparation, chemical characterisation, mechanical testing, cell culture
Mischa Zelzer Biointerfaces; biomaterials; peptide materials; hydrogels; computational material science Surface modification and analysis; polymerisation kinetics; light and enzyme responsive materials; material characterisation

View our publications

World-class research at the University of Nottingham

University Park
Nottingham
NG7 2RD
+44 (0) 115 951 5151
research@nottingham.ac.uk