I work at the interface of computational modelling, MRI physics, and neuroscience developing novel methodology for neuroimage analysis. Broadly, my scientific goal is to achieve a better understanding of the structural and functional organisation of the brain at a systems level. To this end, my group (https://conilab.nottingham.ac.uk) develops computational methods and algorithmic/modelling frameworks for mapping brain connections and neuronal tissue microstructure using MRI, all the way from image reconstruction and processing to high-throughput analytics.
My algorithms and software tools enable imaging-derived phenotyping at scale and are widely used worldwide. In basic neuroscience for untangling the complexity of the human brain and study evolution and neurodevelopment. In clinical neuroscience for brain-symptom mapping and imaging-guided treatment targeting.
Over the years, I have been a major contributor to Open Science initiatives and to large-scale international efforts for pushing the boundaries in neuroimaging technologies (Human Connectome Projects, UK Biobank, NIH Centre for Mesoscale Connectomics). I have attracted funding from national and international funders (UKRI, European Research Council, US National Institutes of Health), charities (Wellcome Trust) and industry.
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Developing novel forms of neurotechnology
National Institutes of Health (NIH) Centre for Mesoscale, Connectomics, Developing cutting-edge technologies for mapping brain connections for precision diagnostics and therapeutics.
On stability of Canonical Correlation Analysis and Partial Least Squares with application to brain-behavior associations. Helmer M, Warrington S, Mohammadi-Nejad AR, Ji JL, Howell A, Rosand B, Anticevic A, Sotiropoulos SN*, Murray JD* Communications Biology 7:217 (2024)
Denoising Diffusion MRI: Considerations and implications for analysis. Manzano-Patron JP, Moeller S, Andersson JLR, Ugurbil K, Yacoub E, Sotiropoulos SN Imaging Neuroscience 2 (2024)
Concurrent mapping of brain ontogeny and phylogeny within a common space: standardised tractography and applications. Warrington S, Thompson E, Bastiani M, Dubois J, Baxter L, Slater R, Jbabdi S, Mars RB, Sotiropoulos SN Science Advances 8:42 (2022)
XTRACT - Standardised protocols for automated tractography in the human and macaque brain. Warrington S, Bryant KL, Khrapitchev AA, Sallet J, Charquero-Ballester M, Douaud G, Jbabdi S, Mars RB, Sotiropoulos SN Neuroimage 217:116923 (2020)
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Hierarchical Heterogeneity across Human Cortex Shapes Large-Scale Neural Dynamics. Demirtas M, Burt JB, Helmer M, Ji JL, Adkinson BD, Glasser MF, Van Essen DC, Sotiropoulos SN, Anticevic A, Murray JD Neuron 101:1181-1194 (2019)
The University of NottinghamUniversity Park Nottingham, NG7 2RD