School of Life Sciences

SLIM Publications


 Jennifer T. Patel, Hannah R. Belsham, Alexandra J. Rathbone, Bill Wickstead, Christopher Gell, Claire T. Friel The family-specific α4-helix of the kinesin-13, MCAK, is critical to microtubule end recognition Open Biol. 2016 6 160223; DOI: 10.1098/rsob.160223.

Dunajová L, Cash E, Markus R, Rochette S, Townley AR, Wheatley SP. The NH2 terminus of survivin is a mitochondrial targeting sequence and C-Src regulator. JCell Sci. 2016 May 31. pii: jcs.183277. 

Willson BJ, Kovács K, Wilding-Steele T, Markus R, Winzer K, Minton NP. Production of a functional cell wall-anchored minicellulosome by recombinantClostridium acetobutylicum ATCC 824. Biotechnol Biofuels. 2016 May 23;9:109. 

Xu L, Nwosu LN, Burston JJ, Millns PJ, Sagar DR, Mapp PI, Meesawatsom P, Li L,Bennett AJ, Walsh DA, Chapman V. The anti-NGF antibody muMab 911 both preventsand reverses pain behaviour and subchondral osteoclast numbers in a rat model of osteoarthritis pain. Osteoarthritis Cartilage. 2016 May 18. pii:S1063-4584(16)30101-7. doi: 10.1016/j.joca.2016.05.015

Goode A, Butler K, Long J, Cavey J, Scott D, Shaw B, Sollenberger J, Gell C, Johansen T, Oldham NJ, Searle MS, Layfield R. Defective recognition of LC3B bymutant SQSTM1/p62 implicates impairment of autophagy as a pathogenic mechanism inALS-FTLD. Autophagy. 2016 May 9:1-11.


Loreto, A, Di Stefano, M, Gering, M, and Conforti1, L. Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca2+ Influx but Only Modestly Influenced by Mitochondria. Cell Reports. 2015

Behnke JM, Stewart A, Bajer A, Grzybek M, Harris PD, Lowe A, Ribas A, Smales L, Vandegrift KJ. Bank voles (Myodes glareolus) and house mice (Mus musculusmusculus; M. m. domesticus) in Europe are each parasitized by their own distinct species of Aspiculuris (Nematoda, Oxyurida). Parasitology. 2015 142(12):1493-505. 

Aljaberi AM, Webster JR, Wheatley SP. Mitotic activity of survivin is regulated by acetylation at K129. Cell Cycle. 2015 Jun 3;14(11):1738-47.

Luoga W, Mansur F, Buttle DJ, Duce IR, Garnett MC, Lowe A, Behnke JM. The relative anthelmintic efficacy of plant-derived cysteine proteinases on intestinal nematodes. J Helminthol. 2015 Mar;89(2):165-74. 

Louzao I, Sui C, Winzer K, Fernandez-Trillo F, Alexander C. Cationic polymer mediated bacterial clustering: Cell-adhesive properties of homo- and copolymers. Eur J Pharm Biopharm. 2015 Jun 9. 

Saeed A, Francini N, White L, Dixon J, Gould T, Rashidi H, Al Ghanami RC, Hruschka V, Redl H, Saunders BR, Alexander C, Shakesheff KM. A thermoresponsive and magnetic colloid for 3D cell expansion and reconfiguration. Adv Mater. 2015 Jan 27;27(4):662-8. 

Xuesen Zeng, Sacha J. Mooney, Craig J. Sturrock, Assessing the effect of fibre extraction processes on the strength of flax fibre reinforcement, Composites Part A: Applied Science and Manufacturing, Volume 70, March 2015, Pages 1-7.

Chua JX, Vankemmelbeke M, McIntosh RS, Clarke PA, Moss R, Parsons T, Spendlove I, Zaitoun AM, Madhusudan S, Durrant LG. Monoclonal Antibodies Targeting LecLex-Related Glycans with Potent Antitumor Activity. Clin Cancer Res. 2015 Jul 1;21(13):2963-74.

Kilpatrick LE, Humphrys LJ, Holliday ND. A G protein-coupled receptor dimer imaging assay reveals selectively modified pharmacology of neuropeptide Y Y1/Y5 receptor heterodimers. Mol Pharmacol. 2015 Apr;87(4):718-32.

Al-Mubarak F, Daly J, Christie D, Fountain D, Dunham SP. Identification of morphological differences between avian influenza A viruses grown in chicken and duck cells. Virus Res. 2015 Mar 2;199:9-19.

Wheatley SP. The functional repertoire of survivin's tails. Cell Cycle. 2015;14(2):261-8.

Ivanov DP, Parker TL, Walker DA, Alexander C, Ashford MB, Gellert PR, Garnett MC. In vitro co-culture model of medulloblastoma and human neural stem cells for drug delivery assessment. J Biotechnol. 2015 Jul 10;205:3-13.

Di Stefano M, Nascimento-Ferreira I, Orsomando G, Mori V, Gilley J, Brown R, Janeckova L, Vargas ME, Worrell LA, Loreto A, Tickle J, Patrick J, Webster JR, Marangoni M, Carpi FM, Pucciarelli S, Rossi F, Meng W, Sagasti A, Ribchester RR, Magni G, Coleman MP, Conforti L. A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration. Cell Death Differ. 2015 May;22(5):731-42.

Kelly S, Chapman RJ, Woodhams S, Sagar DR, Turner J, Burston JJ, Bullock C, Paton K, Huang J, Wong A, McWilliams DF, Okine BN, Barrett DA, Hathway GJ, Walsh DA, Chapman V. Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain. Ann Rheum Dis. 2015 Jan;74(1):252-9.


Alqahtani F, Mahdavi J, Wheldon LM, Vassey M, Pirinccioglu N, Royer PJ, Qarani SM, Morroll S, Stoof J, Holliday ND, Teo SY, Oldfield NJ, Wooldridge KG, Ala'Aldeen DA. Deciphering the complex three-way interaction between the non-integrin laminin receptor, galectin-3 and Neisseria meningitidis. Open Biol. 2014 Oct;4(10). pii: 140053.

Gherbi K, Briddon SJ, Hill SJ. Detection of the secondary, low-affinity β1 -adrenoceptor site in living cells using the fluorescent CGP 12177 derivative BODIPY-TMR-CGP. Br J Pharmacol. 2014 Dec;171(23):5431-45.

Corriden R, Kilpatrick LE, Kellam B, Briddon SJ, Hill SJ. Kinetic analysis of antagonist-occupied adenosine-A3 receptors within membrane microdomains of individual cells provides evidence of receptor dimerization and allosterism. FASEB J. 2014 Oct;28(10):4211-22. doi: 10.1096/fj.13-247270.

Saxon EB, Jackson RW, Bhumbra S, Smith T, Sockett RE. Bdellovibrio bacteriovorus HD100 guards against Pseudomonas tolaasii brown-blotch lesions on the surface of post-harvest Agaricus bisporus supermarket mushrooms. BMC Microbiol. 2014 Jun 20;14:163. doi: 10.1186/1471-2180-14-163.

Marangoni M, Adalbert R, Janeckova L, Patrick J, Kohli J, Coleman MP, Conforti L. Age-related axonal swellings precede other neuropathological hallmarks in a knock-in mouse model of Huntington's disease. Neurobiol Aging. 2014 Oct;35(10):2382-93.

Stoddart LA, Kellam B, Briddon SJ, Hill SJ. Effect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization. Br J Pharmacol. 2014 Aug;171(16):3827-44.

Mountford SJ, Liu M, Zhang L, Groenen M, Herzog H, Holliday ND, Thompson PE. Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging. Org Biomol Chem. 2014 May 28;12(20):3271-81.

Jaeger WC, Armstrong SP, Hill SJ, Pfleger KD. Biophysical Detection of Diversity and Bias in GPCR Function. Front Endocrinol (Lausanne). 2014 Mar 5;5:26.

Mahdavi J, Pirinccioglu N, Oldfield NJ, Carlsohn E, Stoof J, Aslam A, Self T, Cawthraw SA, Petrovska L, Colborne N, Sihlbom C, Borén T, Wooldridge KG, Ala'Aldeen DA. A novel O-linked glycan modulates Campylobacter jejuni major outer membrane protein-mediated adhesion to human histo-blood group antigens and chicken colonization. Open Biol. 2014 Jan 22;4:130202.

Aljaberi AM, Webster JR, Wheatley SP. Analysis of the functional repertoire of a mutant form of survivin, K129E, which has been linked to lung cancer. Cancer Cell Int. 2014 Aug 19;14:78. doi: 10.1186/s12935-014-0078-8.

Hill SJ, May LT, Kellam B, Woolard J. Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization. Br J Pharmacol. 2014 Mar;171(5):1102-13.

Vernall AJ, Hill SJ, Kellam B. The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs. Br J Pharmacol. 2014 Mar;171(5):1073-84

Bullock CM, Wookey P, Bennett A, Mobasheri A, Dickerson I, Kelly S. Peripheral calcitonin gene-related peptide receptor activation and mechanical sensitization of the joint in rat models of osteoarthritis pain. Arthritis Rheumatol. 2014 Aug;66(8):2188-200.

Magennis EP, Fernandez-Trillo F, Sui C, Spain SG, Bradshaw DJ, Churchley D, Mantovani G, Winzer K, Alexander C. Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling. Nat Mater. 2014 Jul;13(7):748-55. 

Mansur F, Luoga W, Buttle DJ, Duce IR, Lowe A, Behnke JM. The anthelmintic efficacy of natural plant cysteine proteinases against two rodent cestodes Hymenolepis diminuta and Hymenolepis microstoma in vitro. Vet Parasitol. 2014 Mar 17;201(1-2):48-58. 

Tripathy R, Kunwar PS, Sano H, Renault AD. Transcriptional regulation of Drosophila gonad formation. Dev Biol. 2014 Aug 15;392(2):193-208. 

Dua HS, Faraj LA, Branch MJ, Yeung AM, Elalfy MS, Said DG, Gray T, Lowe J. The collagen matrix of the human trabecular meshwork is an extension of the novel pre-Descemet's layer (Dua's layer). Br J Ophthalmol. 2014 May;98(5):691-7. 

Magennis EP, Fernandez-Trillo F, Sui C, Spain SG, Bradshaw D, Churchley D, Mantovani G, Winzer K, Alexander C. Nature materials. Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling.2014/07/01 00:00; 13(7): 748-755

Magnusson JP, Fernández-Trillo F, Sicilia G, Spain SG, Alexander C. Programmed assembly of polymer-DNA conjugate nanoparticles with optical readout and sequence-specific activation of biorecognition. Nanoscale. 2014 Feb 21;6(4):2368-74. 

Erdozain AM, Morentin B, Bedford L, King E, Tooth D, Brewer C, Wayne D, Johnson L, Gerdes HK, Wigmore P, Callado LF, Carter WG. Alcohol-related brain damage in humans. PLoS One. 2014;9(4):e93586. 

Milner DS, Till R, Cadby I, Lovering AL, Basford SM, Saxon EB, Liddell S, Williams LE, Sockett RE. Ras GTPase-like protein MglA, a controller of bacterial social-motility in Myxobacteria, has evolved to control bacterial predation by Bdellovibrio. PLoS Genet. 2014 Apr;10(4):e1004253.


Burston JJ, Sagar DR, Shao P, Bai M, King E, Brailsford L, Turner JM, Hathway GJ, Bennett AJ, Walsh DA, Kendall DA, Lichtman A, Chapman V. Cannabinoid CB2 receptors regulate central sensitization and pain responses associated with osteoarthritis of the knee joint. PLoS One. 2013 Nov 25;8(11):e80440.

Mahdavi J, Royer PJ, Sjölinder HS, Azimi S, Self T, Stoof J, Wheldon LM, Brännström K, Wilson R, Moreton J, Moir JW, Sihlbom C, Borén T, Jonsson AB, Soultanas P, Ala'Aldeen DA. Pro-inflammatory cytokines can act as intracellular modulators of commensal bacterial virulence. Open Biol. 2013 Oct 9;3(10):130048.

King MV, Kurian N, Qin S, Papadopoulou N, Westerink BH, Cremers TI, Epping-Jordan MP, Le Poul E, Ray DE, Fone KC, Kendall DA, Marsden CA, Sharp TV. Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition. Neuropsychopharmacology. 2014 Jan;39(2):464-76.

Vernall AJ, Stoddart LA, Briddon SJ, Ng HW, Laughton CA, Doughty SW, Hill SJ, Kellam B. Conversion of a non-selective adenosine receptor antagonist into A3-selective high affinity fluorescent probes using peptide-based linkers. Org Biomol Chem. 2013 Sep 14;11(34):5673-82

Corriden R, Self T, Akong-Moore K, Nizet V, Kellam B, Briddon SJ, Hill SJ. Adenosine-A3 receptors in neutrophil microdomains promote the formation of bacteria-tethering cytonemes. EMBO Rep. 2013 Aug;14(8):726-32.

Capeness MJ, Lambert C, Lovering AL, Till R, Uchida K, Chaudhuri R, Alderwick LJ, Lee DJ, Swarbreck D, Liddell S, Aizawa S, Sockett RE. Activity of Bdellovibrio hit locus proteins, Bd0108 and Bd0109, links Type IVa pilus extrusion/retraction status to prey-independent growth signalling. PLoS One. 2013;8(11):e79759. 

Lambert C, Sockett RE. Nucleases in Bdellovibrio bacteriovorus contribute towards efficient self-biofilm formation and eradication of preformed prey biofilms. FEMS Microbiol Lett. 2013 Mar;340(2):109-16. 

Crossman LC, Chen H, Cerdeño-Tárraga AM, Brooks K, Quail MA, Pineiro SA, Hobley L, Sockett RE, Bentley SD, Parkhill J, Williams HN, Stine C. A small predatory core genome in the divergent marine Bacteriovorax marinus SJ and the terrestrial Bdellovibrio bacteriovorus. ISME J. 2013 Jan;7(1):148-60. 

Guttery DS, Pittman JK, Frénal K, Poulin B, McFarlane LR, Slavic K, Wheatley SP, Soldati-Favre D, Krishna S, Tewari R, Staines HM. The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development. PLoS Pathog. 2013 Feb;9(2):e1003191. 

 Guttery DS, Pittman JK, Frénal K, Poulin B, McFarlane LR, Slavic K, Wheatley SP, Soldati-Favre D, Krishna S, Tewari R, Staines HM. The Plasmodium berghei Ca2+/H+ Exchanger, PbCAX, Is Essential for Tolerance to Environmental Ca2+ during Sexual Development. PLoS Pathogens. 2013/02/01 00:00; 9(2): e1003191


Kay C, Lawler K, Self TJ, Dyall SD, Kerr ID. Localisation of a family of complex-forming β-barrels in the T. vaginalis hydrogenosomal membrane. FEBS Lett. 2012 Nov 16;586(22):4038-45.

Stoddart LA, Vernall AJ, Denman JL, Briddon SJ, Kellam B, Hill SJ. Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol. 2012 Sep 21;19(9):1105-15.

Valentin-Hansen L, Groenen M, Nygaard R, Frimurer TM, Holliday ND, Schwartz TW. The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor. J Biol Chem. 2012 Sep 14;287(38):31973-82.

Kay C, Woodward KD, Lawler K, Self TJ, Dyall SD, Kerr ID. The ATP-binding cassette proteins of the deep-branching protozoan parasite Trichomonas vaginalis. PLoS Negl Trop Dis. 2012;6(6):e1693.

Kilpatrick LE, Holliday ND. Dissecting the pharmacology of G protein-coupled receptor signaling complexes using bimolecular fluorescence complementation. Methods Mol Biol. 2012;897:109-38.

Kilpatrick LE, Briddon SJ, Holliday ND. Fluorescence correlation spectroscopy, combined with bimolecular fluorescence complementation, reveals the effects of β-arrestin complexes and endocytic targeting on the membrane mobility of neuropeptide Y receptors. Biochim Biophys Acta. 2012 Jun;1823(6):1068-81.

Ayling LJ, Briddon SJ, Halls ML, Hammond GR, Vaca L, Pacheco J, Hill SJ, Cooper DM. Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu. J Cell Sci. 2012 Feb 15;125(Pt 4):869-86.

Watson SJ, Brown AJ, Holliday ND. Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol Pharmacol. 2012 May;81(5):631-42.

Vernall AJ, Stoddart LA, Briddon SJ, Hill SJ, Kellam B. Highly potent and selective fluorescent antagonists of the human adenosine A₃ receptor based on the 1,2,4-triazolo[4,3-a]quinoxalin-1-one scaffold. J Med Chem. 2012 Feb 23;55(4):1771-82.

Rose RH, Briddon SJ, Hill SJ. A novel fluorescent histamine H(1) receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands. Br J Pharmacol. 2012 Mar;165(6):1789-800.

Daniel M, Imtiaz-Umer S, Fergie N, Birchall JP, Bayston R. Bacterial involvement in otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2012 Oct;76(10):1416-22. 

Hey F, Czyzewicz N, Jones P, Sablitzky F. DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies. J Biol Chem. 2012 Sep 7;287(37):31073-84.


Sagar DR, Burston JJ, Hathway GJ, Woodhams SG, Pearson RG, Bennett AJ, Kendall DA, Scammell BE, Chapman V. The contribution of spinal glial cells to chronic pain behaviour in the monosodium iodoacetate model of osteoarthritic pain. Mol Pain. 2011 Nov 17;7:88.

Haider AJ, Briggs D, Self TJ, Chilvers HL, Holliday ND, Kerr ID. Dimerization of ABCG2 analysed by bimolecular fluorescence complementation. PLoS One. 2011;6(10):e25818.

May LT, Bridge LJ, Stoddart LA, Briddon SJ, Hill SJ. Allosteric interactions across native adenosine-A3 receptor homodimers: quantification using single-cell ligand-binding kinetics. FASEB J. 2011 Oct;25(10):3465-76.

Briddon SJ, Kellam B, Hill SJ. Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells. Methods Mol Biol. 2011;746:211-36.

Evans EL, Saxton J, Shelton SJ, Begitt A, Holliday ND, Hipskind RA, Shaw PE. Dimer formation and conformational flexibility ensure cytoplasmic stability and nuclear accumulation of Elk-1. Nucleic Acids Res. 2011 Aug;39(15):6390-402.

Baker JG, Hill SJ, Summers RJ. Evolution of β-blockers: from anti-anginal drugs to ligand-directed signalling. Trends Pharmacol Sci. 2011 Apr;32(4):227-34.

Sivertsen B, Lang M, Frimurer TM, Holliday ND, Bach A, Els S, Engelstoft MS, Petersen PS, Madsen AN, Schwartz TW, Beck-Sickinger AG, Holst B. Unique interaction pattern for a functionally biased ghrelin receptor agonist. J Biol Chem. 2011 Jun 10;286(23):20845-60.


Hill SJ, Williams C, May LT. Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies. Br J Pharmacol. 2010 Nov;161(6):1266-75.

James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y, Lagos D, Chu CY, Rana TM, Morley SJ, Longmore GD, Bushell M, Sharp TV. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing. Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12499-504.

May LT, Self TJ, Briddon SJ, Hill SJ. The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells. Mol Pharmacol. 2010 Sep;78(3):511-23.

Kilpatrick LE, Briddon SJ, Hill SJ, Holliday ND. Quantitative analysis of neuropeptide Y receptor association with beta-arrestin2 measured by bimolecular fluorescence complementation. Br J Pharmacol. 2010 Jun;160(4):892-906.


Williams C, Hill SJ. GPCR signaling: understanding the pathway to successful drug discovery. Methods Mol Biol. 2009;552:39-50.

Orihuela CJ, Mahdavi J, Thornton J, Mann B, Wooldridge KG, Abouseada N, Oldfield NJ, Self T, Ala'Aldeen DA, Tuomanen EI. Laminin receptor initiates bacterial contact with the blood brain barrier in experimental meningitis models. J Clin Invest. 2009 Jun;119(6):1638-46.

Ghosh TK, Song FF, Packham EA, Buxton S, Robinson TE, Ronksley J, Self T, Bonser AJ, Brook JD. Physical interaction between TBX5 and MEF2C is required for early heart development. Mol Cell Biol. 2009 Apr;29(8):2205-18.  




Easton N, Steward C, Marshall F, Fone K, Marsden C. (2007) Effects of amphetamine isomers, methylphenidate and atomoxetine on synaptosomal and synaptic vesicle accumulation and release of dopamine and noradrenaline in vitro in the rat brain. Neuropharmacology 52: 405-414.

Mayhew TM. (2007) Quantitative Immunoelectron Microscopy. Alternative ways of assessing subcellular patterns of gold labelling. Chapter 15 In: Methods in Molecular Biology, vol 369, Electron Microscopy: Methods and Protocols, 2nd edition. Kuo J Ed, Humena Press Inc, Totowa, NJ, USA.

Allen L, Anderson S, Wender R, Meakin P, Ransom BR, Ray DE, Brown AM. (2006) Fructose supports energy metabolism of some, but not all, axons in adult mouse optic nerve. J Neurophysiol 95: 1917-1925.
Vizcay-Barrena G, Wilson ZA. (2006) Altered tapetal PCD and pollen wall development in the Arabidopsis ms1 mutant. J Exp Bot, 57: 2709-2717.



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