Scientist
e-mail: Lee.Wheldon@nottingham.ac.uk
Tel: +44 (0)115 8230743
The primary thrust of my work in the CBS Nottingham is to explore the interaction of N.meningitidis (organism and candidate molecules) with host cells and the recruitment of potential signalling molecules/pathways, focussing on an already identified host cell receptor, the 37kDa LRP/67kDa laminin receptor. This has been extended to potential post-translational modification of this receptor and identification of the exact nature of the mature (67 kDa) Laminin Receptor.
Prior to this post I was involved with several different projects, primarily concerned with regulatory aspects of Fibroblast Growth Factor receptor (FGFR) signalling at both the level of receptor and analysis of downstream signalling partners and parameters. More recently, work had focussed on a family of FGFR-associated proteins, Fibronectin Leucine Rich Transmembrane (FLRT) proteins, and the role of FGFR and FLRT tyrosine phosphorylation in regulation of function and downstream signalling.
Publications
Wheldon LM, Haines BP, Rigby PW, Heath JK. (2009) FLRT1 regulates Neurite Outgrowth: a novel futile cycle mechanism employing Src family kinase-mediated FGF Receptor-Dependent FLRT Phosphorylation. (Manuscript under review).
Wheldon LM, Khodabukus N, Patey SJ, Smith TG, Heath JK, Hajihosseini MK. (2009) Identification and characterization of an inhibitory fibroblast growth factor receptor 2 (FGFR2) molecule that is up-regulated in a mouse model of Apert Syndrome. (Manuscript in preparation).
Akbarzadeh S, Wheldon LM, Sweet SM, Talma S, Mardakheh FK, Heath JK. (2008) The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src. PLoS ONE. Mar 26;3(3):e1873.
Vecchione A, Cooper HJ, Trim KJ, Akbarzadeh S, Heath JK, Wheldon LM. (2007) Protein partners in the life history of activated fibroblast growth factor receptors. Proteomics. Dec;7(24):4565-78.
Haines BP, Wheldon LM, Summerbell D, Heath JK, Rigby PW. (2006) Regulated expression of FLRT genes implies a functional role in the regulation of FGF signalling during mouse development. Dev Biol. Sep 1;297(1):14-25.
Li X, Brunton VG, Burgar HR, Wheldon LM, Heath JK. (2004) FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity. J Cell Sci. Dec 1;117(Pt 25):6007-17.
Li X, Wheldon L, Heath JK. (2003) Sprouty: a controversial role in receptor tyrosine kinase signalling pathways. Biochem Soc Trans. Dec;31(Pt 6):1445-6. Review.
Wheldon LM, Nahorski SR, Willars GB. (2001) Inositol 1,4,5-trisphosphate-independent calcium signalling by platelet-derived growth factor in the human SH-SY5Y neuroblastoma cell. Cell Calcium. Aug;30(2):95-106.
Contact details:
Centre for Biomolecular Sciences
University of Nottingham
University Park
Nottingham NG7 2RD
Tel: +44 (0)115 44115846 8001
E-mail: lee.wheldon@nottingham.ac.uk