Arthritis Research UK Pain Centre
   
   
     
  

Centre membership

Members of the Centre are encouraged to participate in our regular series of scientific and strategic meetings.  The Centre is a key component of the University of Nottingham’s clinical translational research strategy, and both the University and Nottingham University Hospitals NHS Trust strongly support the Centre’s activities and infrastructure, including patient and public engagement and involvement, staff development, and the Centre’s research agenda. 

Centre membership is intended to facilitate interdisciplinary and translational research of the highest quality and should be of mutual benefit to both member and the Centre. Collectively the members of the Centre are expected to contribute to sustaining the research goals of the Arthritis Research UK Pain Centre via publications, presentations, grant applications and other communications. The Centre will acknowledge and publicise its member’s successes through its reports and this website. 

Current Centre members are:

Sadaf Ashraf profile
Sadaf Ashraf
Research Fellow, School of Pharmacy 

show/hide full profile...

Sadaf is a Research Fellow in the Division of Molecular Therapeutics and Formulation within the School of Pharmacy. Sadaf is currently working on the ARUK funded project investigating whether cordycepin, a polyadenylation inhibitor, has the potential to reduce pain and pathology in preclinical models of osteoarthritis. Sadaf undertook her PhD from the University of Nottingham. Her thesis investigated the role of inflammation and angiogenesis in the progression of joint damage and pain in osteoarthritis. She then went on to pursue a postdoctoral position (2012-2015) at the Centre for Experimental Medicine within Queen’s University Belfast, Northern Ireland, investigating potential therapeutic targets to control retinal angiogenesis in diabetic retinopathy. Further information

   

 DAuer
Professor Dorothee Auer
Professor of Neuroimaging, Faculty of Medicine & Health Science

show/hide full profile...

Dorothee's current research interest is to develop imaging biomarkers in the field of Clinical Neurosciences by using advanced MRI techniques. The aims are (1) to understand the pathophysiology of diseases or complex symptoms across diseases, (2) to improve diagnostic accuracy, and (3) to predict and assess therapeutic interventions. Methods used are MR proton spectroscopy, diffusion tensor imaging, perfusion, relaxometry, high resolution carotid imaging and combined electrophysiological/functional MRI with special interst in brian connectivity analysis. The clinical applications are for prediction of risk of stroke, monitoring neurodegeneration, classification and response prediction in paediatric and adult brain cancer, and understanding the neural basis of pain and depression treatment.  Further information.

 

 davebarrett
Professor Dave Barrett
Pharmacy, University Park

show/hide full profile...

Dave's expertise are in: Metabolic profiling of biofluids and tissues, lipid analysis, metabolomics, biomarker discovery, mass spectrometry imaging. Further information

 

Tobias-Bast
Dr Tobias Bast
School of Psychology

show/hide full profile...

Tobias studies the brain mechanisms of cognition and behaviour. To this end, he mainly combines in vivo neurobiological methods with behavioural testing in rodent models. Tobias’ research focuses on how a brain circuit consisting of the hippocampus, prefrontal cortex and connected subcortical regions mediates and integrates important cognitive functions – including memory and attention – and other behavioural processes (emotional, motivational, sensorimotor). In addition, he studies how dysfunction in this brain circuit causes cognitive and behavioural deficits.  Further information.

 

M_Batt-image
Professor Mark Batt
Medicine, Queen's Medical Centre 

show/hide full profile...

Prof Mark Batt is a Consultant in Sport and Exercise Medicine at The Centre for Sports Medicine, Nottingham University Hospitals NHS Trust. He has a busy NHS practice and a past Fellow at The NHS Institute for Innovation & Improvement.

He graduated from Cambridge University Medical School in 1984 and trained in Family Medicine. He obtained a Diploma in Sports Medicine from the University of London in 1991 and completed a fellowship in Sports Medicine at the University of California, Davis (UCD) in 1993. The next two years were spent as a faculty member in Family Medicine at UCD and as a team physician at the University of California, Berkeley.

Since 1995, he has been in Nottingham as a Consultant/Senior Lecturer in Sport and Exercise Medicine at the Nottingham University Hospitals: appointed Special Professor in 2004. He served for 2½ years as clinical director for Trauma and Orthopaedics. He is the Q-Active programme director – a workplace health and wellness programme based at The Queens Medical Centre: www.qactive.co.uk

He has served as a consultant for The England and Wales Cricket Board, The Rugby Football League, British Gymnastics and The English Institute of Sport. Since 2000 he has been a physician for The Wimbledon Tennis Championships, ATP and the WTA.

He is immediate past-President of the Faculty of Sport & Exercise Medicine and is a past Chairman of the Specialist Advisory Committee in SEM. He chaired the work-group that produced the successful case for Sport & Exercise Medicine as a specialty of medicine (2005).

His research interests include: Overuse injuries, OA and Workplace Wellness. He is the Director of the Arthritis Research UK Centre for Sport, Exercise & OA, which opened in Jan 2013.

He is married with two children. He enjoys a variety of sports, outdoor pursuits and gardening, none of which he does tremendously well!  Further information

 

Molecular-Cell-Biology
Dr Andrew Bennett
School of Life Sciences, Queen's Medical Centre 

show/hide full profile...

Interests:

  • Nutrient regulation of carbohydrate and lipid metabolism.
  • Regulation of gene expression by lipids and carbohydrate.
  • Role of steroid hormone transcription factors in health and disease

Further information 

    

 hollyblake 
Dr Holly Blake
School of Health Sciences, Queen's Medical Centre

show/hide full profile...

Holly is Associate Professor of Behavioural Science at the University of Nottingham School of Health Sciences. She is a chartered health psychologist with an interest in health behaviour change in a range of populations (adults, children, long-term conditions) and settings (workplaces, hospitals, community). This research has included patients with rheumatoid arthritis, osteoarthritis and long-term pain, and has involved interventions to support self-management of long-term conditions, investigations relating to patient involvement in care, technology-based health communications (e.g. online learning tools, website, email and mobile phone messaging), and behavioural interventions to promote physical activity, self-care practices and uptake of health services.  Further information. Further information.

   

VC
Professor Victoria Chapman
Professor of Neuropharmacology, Life Sciences

show/hide full profile...

Vicky is Deputy Director of the Arthritis Research UK Pain Centre and has responsibility for the management of pre-clinical studies. Her research has contributed to advances in the understanding of peripheral and central processing of nociceptive inputs and the mechanisms associated with the manifestation of aberrant pain responses associated with chronic pain states. She has a background in neuropharmacology (PhD under the supervision of Professor Anthony Dickenson), which provides a strong foundation for her interest in the investigation of disease specific mechanisms of chronic pain responses, and the identification of novel analgesic targets in particular relevant to osteoarthritis pain. Vicky has experience of being PI, managing and delivering on inter-disciplinary research projects, funded by the Welcome Trust, the MRC and pharmaceutical industry.  Further information.

 corneliademoor
Dr Cornelia de Moor
Associate Professor in RNA Biology, School of Pharmacy

show/hide full profile...

Cornelia is Associate Professor in RNA Biology at the School of Pharmacy in Nottingham. Her work focusses on post-transcriptional mechanisms of gene expression, especially mRNA polyadenylation, stability and translation. There is increasing evidence that these processes play a large role in the regulation of inflammation, neuronal plasticity and tissue remodelling, and that they can be targeted in diseases where such processes are dysregulated, such as in arthritis. Her work also has relevance for cancer. Further information

 

MD_PortrainNew-Image
Professor Michael Doherty
Professor of Rheumatology, Medicine

show/hide full profile...

Michael is Professor of Rheumatology and Head of Division of Rheumatology, Orthopaedics and Dermatology, School of Medicine, University of Nottingham. His main research interests are osteoarthritis (OA), gout, calcium pyrophosphate crystal deposition (CPPD), placebo/contextual response and evidence based medicine (EBM). He has expertise in clinical and epidemiological studies, community-based clinical trials, systematic reviews and meta-analyses.

He has over 300 original research publications and was awarded the OA Research Society International (OARSI) Clinical Research Award for 2012. He is a past editor of Annals of the Rheumatic Diseases (1992-99), has co-chaired EULAR Task Forces for evidence-based recommendations for OA, gout and CPPD arthritis, and has been involved as a clinical expert in NICE appraisals relating to OA and gout.  He was awarded a Lord Dearing prize for teaching and learning in 2001 and was the Royal College of Physicians Watson Smith Lecturer in 2011. Further information

 

Lucy-Donaldson 2
Prof Lucy Donaldson
Life Sciences, Queen's Medical Centre 

show/hide full profile...

Lucy is a neurophysiologist with expertise in neuronal function in acute and chronic pain, particularly in arthritis. Lucy studied for her undergraduate (Dentistry BDS, Neuroscience BSc (Hons) and postgraduate (PhD, Pharmacology) degrees at the University of Edinburgh. From there she moved to a post-doctoral position at the University of California, working on several projects including tachykinin receptor expression and function (with Michael Hanley), neuronal cation-chloride co-transporters (with John Payne) and protein kinases (with Don Walsh). In 1996 she was appointed to a Lectureship at the University of Leicester, where she worked on neuronal prostaglandins in collaboration with Blair Grubb. In 1999 she moved to the Dept of Physiology, University of Bristol. She has worked on multiple projects since then including TRP channel, cyclooxygenase and galanin contributions to primary afferent nociceptor function (MRC, Arthritis Research UK funded), neuronal mechanisms in arthritic symmetry (Wellcome Trust funded), descending prostanergic facilitatory control systems (BBSRC, MRC funded, with Prof Bridget Lumb), mTOR peripheral translation mechanisms (MRC funded, with Profs Lumb and Hunt), and most recently vascular endothelial growth factors in neuroprotection and pain (funded by Diabetes UK and Arthritis Research UK). Further information.

 

 A Drummond
Professor Avril Drummond
School of Health Sciences, Queen's Medical Centre

show/hide full profile...

Avril is an occupational therapist by professional background. She is Professor of Healthcare Research, Deputy Head of School and Director of Research in the School of Health Sciences. She is primarily interested in evaluating rehabilitation interventions after joint replacement, in falls reduction and management and with the ageing population. Her expertise is in evaluating complex interventions particularly using mixed methods and randomized controlled trial designs.

She is currently involved in several trials; HippotyHop- evaluating hip precautions after hip replacement; OPAL- Occupational Advice for patients undergoing Arthroplasty of the lower limb: CORKA- Community based rehabilitation after knee arthroplasty and OTIS-Occupational therapist home assessment and modification for prevention of falls.  Further information

  

Eamonn-Ferguson-new
Professor Eamonn Ferguson
Psychology, University Park campus

show/hide full profile...

Eamonn Ferguson (BSc PhD) is Professor of Health Psychology at the University of Nottingham (chartered health and occupational psychologist). His research focuses on the role of personality traits with respect to health outcomes (e.g., symptom perceptions, drug taking, and adherence), pro-social behaviour (charitable donations, blood/organ donation) and medical selection and training. He is the co-founding president of the British Society for the Psychology of Individual Differences (www.bspid.org.uk/). His work incorporates a mixture of lab based experiments using economic games and pain perception, field based work using ecological momentary sampling methods and intervention studies. He also has a long standing interest in the structure and assessment of traits using a variety of psychometric and taxometric procedures. Further information

  

 Gershkovich photo
Dr Pavel Gershkovich
Pharmacy, University Park campus

show/hide full profile...

Pavel Gershkovich is an Assistant Professor of Pharmacokinetics in the School of Pharmacy, University of Nottingham.

His research interests include the following areas:

1. Improvement of the efficiency, selectivity and safety profile of pharmacological therapy based on knowledge of phathophysiology of disease states.

2. Intestinal absorption of drugs, including the mechanisms of intestinal absorption and novel methods to overcome barriers to systemic bioavailability of orally administered drugs.

3. Effects of disease states on pharmacokinetics and pharmacodynamics of drugs.

4. Effect of food and its composition on absorption, disposition, action and toxicity of drugs.

Research in his laboratory has direct clinical significance, i.e., translational research. It is accomplished by an active collaboration with medical clinicians, including at hospital interface. Further information

  

pennygowland
Professor Penny Gowland
School of Physics and Astronomy

show/hide full profile...

Penny has worked on developing quantitative MR techniques to answer a variety of biomedical questions for more than 25 years. She has particular interests in techniques for structural and functional neuroimaging at 7T, and the interactions of electromagnetic fields with the human body. She has worked at Nottingham most of her career having initially done her PhD at the Institute of Cancer Research in Sutton. Further information.

 

P Gowler_Image 2016-11-29 at 14.16.14
Peter Gowler
Research Fellow, School of Life Sciences

show/hide full profile...

Peter is a research associate in the Arthritis Research UK Pain Centre. Previously, he had completed his bachelor’s degree in neuroscience at the University of St Andrews.  Peter is currently in the final stages of his PhD within the
centre, supervised by Professor Victoria Chapman. His thesis is particularly interested in the role of the neurotrophins in mediating chronic joint pain in preclinical models of osteoarthritis. Peter also established a slow progressing murine model of osteoarthritis in the UK Pain Centre. He is currently investigating the time dependent changes in peripheral inflammation in this model of osteoarthritis.

  

PLGreenhaff
Professor Paul Greenhaff
Professor of Muscle Metabolism, School of Life Sciences

show/hide full profile...

Paul is Professor of Muscle Metabolism and head of the Metabolic and Molecular Physiology research group in the School of Life Sciences at the University of Nottingham. He is also deputy director of the Medical Research Council/Arthritis Research UK Centre for Musculoskeletal Ageing Research and a member of the Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis. Current research interests are focussed on the control and integration of muscle fuel utilisation in ageing, inactivity, exercise and surgical trauma, and the molecular regulation of muscle mass in ageing, immobilisation, inactivity, exercise training, inflammation and statin myopathy. Recent and current research projects are funded by Arthritis Research UK, the Biotechnology and Biological Sciences Research Council (BBSRC), Dunhill Medical Trust, industry and the Medical Research Council. Further information 

Michelle-Hall
Dr Michelle Hall
Lecturer, Health Sciences, City Hospital  

show/hide full profile...

Michelle is a physiotherapist who has worked extensively in the field of musculoskeletal rehabilitation and rheumatology and is currently a lecturer in the Division of Physiotherapy at the University of Nottingham.  In 2009 she was awarded a 3 year Allied Health Professionals Fellowship by Arthritis Research UK to investigate the relationships between knee pain, radiographic severity and ultrasound features of inflammation in the community. Michelle’s research interests include developing effective strategies for managing knee OA in the community and enhancing the contextual effect of treatment in OA. Further information.

 

 J Harris_20170612_133639
 Dr John Harris
 Division of Animal Sciences, Sutton Bonington campus 

show/hide full profile...

John is a neurophysiologist who studies spinally organised reflex responses in acute and chronic pain states with the aim of developing improved analgesic therapies. His research group is therefore interested in studying the organisation of withdrawal reflexes per se to see how this organisation may change in chronic pain as well as looking pharmacologically at molecular mechanisms underlying chronic pain using electrophysiological recordings of spinal reflexes as a measure of central nervous system excitability. In particular his group is interested in the modulation of spinal cord excitability by inhibitory and facilitatory supraspinal pathways and how this changes in pain states. In addition to measuring reflexes in pre-clinical models of osteoarthritis (OA), his current research is investigating potential changes in reflexes in client-owned dogs and cats with OA/chronic joint disease in collaboration with vets at the
University of Bristol and North Carolina State University. In addition his group is investigating spontaneous OA in pigs and their potential as a model for human OA and, in collaboration with members of the University of Nottingham
School of Veterinary Medicine and Science, he is soon to be studying withdrawal reflexes in cattle subject to various painful conditions such as leg/foot lesions and mastitis.

  

GHathwaySDC12072
Dr Gareth Hathway
Life Sciences, Queen's Medical Centre

show/hide full profile...

Gareth's research group is sited within newly refurbished and equipped laboratories within the School of Biomedical Sciences at the University of Nottingham. The broad focus of his research is to understand the underlying neurobiological processes that occur when an individual experiences pain. In particular he is interested in the contribution that supraspinal brainstem centres, the rostral ventral medial medulla (RVM) and the periaqueductal grey (PAG) play in the induction and maintenance of chronic pain and also how these centres influence the postnatal maturation of pain processing and maintain chronic pain states. These supraspinal sites are central to the action of opioid analgesics, and neurones within these regions are able to powerfully inhibit or facilitate the excitability of neurones within the dorsal horn of the spinal cord and therefore are able to decrease or increase the amount of pain an individual experiences. His lab utilises in vivo neurophysiological techniques measuring single-unit neuronal activity, eletromyographic responses and EEG. They also perform immunohistochemical anatomical methods and quantitative PCR. Further information.

 

P-HendrickIMG_9868
Mr Paul Hendrick
Lecturer, Health Sciences, Queen's Medical Centre

show/hide full profile...

Paul graduated as a Physiotherapist from Guys Hospital (London) in 1989.  Paul worked in a range of fields including musculoskeletal and sports rehabilitation and chronic pain management.  Paul undertook his graduate Diploma in Manipulative Theraphy in 1999 and his Masters in 2002 at the University of Otago in New Zealand.  Paul taught on the undergraduate and postgraduate Physiotherapy courses at the University of Otago and completed his PhD in 2011 on the role of physical activity in recovery from low back pain.  Paul is a Lecturer in the Division of Physiotherapy at the University of Nottingham in musculoskeletal rehabilitation, manual therapy, pain management and evidence based practice.  Paul's teaching and research interests include the role of physical activity in chronic disease prevention and management, pain mechanisms in manual theraphy and the links between health information and communication and clinical outcomes. Further information

 

Sarina_DSC_0353
Sarina Iwabuchi
Research Fellow, School of Medicine 

show/hide full profile...

Sarina is a research fellow in the Division of Clinical Neuroscience within the School of Medicine. She is currently working on a project funded by the ARUK investigating the neural mechanisms underlying pain progression in osteoarthritis using various advanced MRI techniques including functional MRI, diffusion imaging and perfusion. She also has an interest in neuromodulation and brain stimulation methods as interventions for chronic pain as well as depression, and developing neuroimaging biomarkers to predict clinical response to such treatments.

  

Marilyn-James-for-pain-centre
Professor Marilyn James 
School of Medicine 

show/hide full profile...

Marilyn has worked as a health economist across a number of different sectors including the NHS at unit and district levels, a large inner city PCT; academia and the private sector, as senior global health economist to AstraZeneca pharmaceuticals. The focus of her research work is applied economic evaluation where she has published and presented widely.

She was the Health Economics Advisor to the National Diabetic Retinopathy Network “Four Nations Group” and was economics advisor to the Department of Health’s National Screening Committee’s Ante Natal Sub Group. She has for many years provided technical and policy advice to Regional R&D directorates in health economics and is a respected health economic reviewer for a number of government bodies and research councils nationally and internationally.  Her current research portfolio is wide and is concentrated upon the practical application of economic evaluation in a number of research settings. These include evaluation in Randomised Controlled Trials (RCTs), ophthalmology, orthopaedics, orthotics, pharmaceuticals and primary care. She was responsible for producing the economic guidance for the National Service Framework in Screening for Diabetic Retinopathy based on original research, economic modelling and evidence review and has recently been awarded a 5 year programme grant in this field. Cost utility analysis has been a further focus using health utility indices such as EuroQol to assist purchasers in making prioritisation decisions. Further information

 

Joe-Kai_IMG_3616
Professor Joe Kai
Professor & Head of Primary Care 

show/hide full profile...

Joe Kai has been an inner city GP (family physician) since 1991 and Professor of Primary Care at Nottingham since 2003. He heads a large and top performing primary care department which is part of the NIHR School of Primary Care Research, and which delivers medical undergraduate teaching across all years of the BM BS course at Nottingham. He leads a range of health professional training, and related research to reduce ethnic inequalities in health care, and in applied genetics, using qualitative, primary care database and trial methods. Further information

 

R-Kerslake
Dr Robert Kerslake
Faculty of Medicine & Health Science, Queen's Medical Centre

show/hide full profile...

Dr Robert Kerslake trained in medicine and radiology in London. After a travelling scholarship to the USA, he took up a research post at the newly formed Magnetic Resonance Research Centre in Hull prior to commencing as a consultant musculoskeletal radiologist in Nottingham. His professional interests include all aspects of musculoskeletal radiology and sports medicine imaging. His research interests have included spinal trauma, lumbar stress injuries and currently encompass various aspects of osteoarthritis imaging, working with the Arthritis Research UK Pain Centre and the Arthritis Research UK Centre for Sports, Exercise and Osteoarthritis in Nottingham.

 

R-Knaggs_Portrait_colour_small-2012
Dr Roger Knaggs
Associate Professor in Clinical Pharmacy

show/hide full profile...

Roger is Associate Professor in Clinical Pharmacy Practice at the University of Nottingham and an advanced pharmacy practitioner at Nottingham University Hospitals NHS Trust, where he works as a member of the multidisciplinary pain management service. He is a Council member of the British Pain Society and regularly provides media comment on issues relating to pain management on behalf of the Royal Pharmaceutical Society.

Roger’s research interests relate to prescribing of analgesic medicines and associated clinical outcomes and healthcare utilisation. Current research is focussing on understanding the implications of the changes in opioid prescribing over recent years and their geographical variation, together with understanding the impact of recent legislative changes related to controlled drugs. Further information.

  

Ravi-Mahajan 
Professor Ravi Mahajan
Anaesthesia & Critical Care, Queen's Medical Centre 

show/hide full profile...

Ravi's research interests are patient safety, outcomes and quality improvement, neuro-vascular regulation and muscle energy regulation.  His international and national roles include, Editor-in-Chief of British Journal of Anaesthesia; Chairman, National Institute of Academic Anaesthesia, Royal College of Anaesthetists, UK; 

Chairman, Subcommittee on Patient Safety, European Society of Anaesthesiology; and Chairman, Data Intelligence Group, Safe Anaesthesia Liaison Group, Royal College of Anaesthetists. Further information

  

Dan McW
Dr. Daniel McWilliams
Post-doctoral research fellow

show/hide full profile...

Daniel McWilliams is a post-doctoral research fellow within the Arthritis Research UK Pain Centre. He has interests in studies of rheumatoid arthritis, osteoarthritis, musculoskeletal pain and central sensitisation/pain mechanisms. His published studies include epidemiological data analysis in longitudinal studies of rheumatoid arthritis, pain mechanisms in rheumatoid arthritis, structural progression of rheumatoid joint damage and osteoarthritis. He also works as part of a team that manages the collection, storage and research into biological samples taken from people with musculoskeletal conditions, or taken post-mortem. Further information

 

 Roshan-das-Nair
Dr Roshan das Nair
Consultant Clinical Psychologist & Honorary Associate Professor

show/hide full profile...

Roshan das Nair is Professor of Clinical Psychology & Neuropsychology. He is a British Psychological Society Chartered Clinical Psychologist and a Health and Care Professions Council Registered Practitioner Psychologist.

After qualifying as a clinical psychologist from the National Institute of Mental Health and Neurosciences in Bangalore, India, he obtained his PhD from the University of Nottingham. Between 2001-2003, Prof das Nair worked as a Lecturer at the University of Zambia, and until November 2016, he was a Consultant Clinical Psychologist with Nottingham University Hospitals NHS Trust. Further information

  

Galina
Dr Galina Pavlovskaya 
Assistant Professor, Translational Imaging, Medicine 

show/hide full profile...

Galina is a MR physicist with the expertise in sodium MRI and microimaging (UTE, MQF) at ultra high field (9.4T), particularly in applying these techniques in exploring new imaging markers in diseases associated with physical stresses i.e. arthritis and injuries in sports medicine. Galina studied for her undergraduate (Soft Condensed Matter Physics) degree at Lomonosov Moscow State University, Moscow, Russia and postgraduate (PhD, Chemical Physics) degree at Clark University, Massachusetts, USA. From there she moved to a post-doctoral position at the National High Magnetic Field Laboratory, Tallahassee, Florida, USA working on MRI of fluid flows in tissues following a second post-doctoral post in MRI of bio-fluid flow in stenotic geometries at Lawrence Berkeley National Laboratory, University of California, Berkeley, USA.  She continued as an independent Researcher at Colorado State University developing hyperpolarised MRI methodology for lung studies and sodium MRI methodology for soft tissues characterisation. In 2009 she was appointed as an Assistant Professor at the University of Nottingham, where she continued to work on hyperpolarisation techniques and sodium methodology developments.   She was promoted to an Associate Professor in 2017, her research is currently funded by MRC, BBSRC, EPSRC and charities. She also contributes to UG teaching in the School of Medicine with a module “Physics of the body” and in the School of Physics and Astronomy with 3rd year research project students. Further information

  

richardpearson  
Dr Richard Pearson
Medicine, Queen's Medical Centre

show/hide full profile...

Richard's interest in pain stems from research into osteoarthritis initiated at the Institute of Orthopaedics, Stanmore, Royal National Orthopaedic Hospital. This was subsequently complemented by investigating peripheral and central nervous system repair strategies in the School of Pharmacy (UoN) in collaboration with the National Institute of Medical Research. In 2003, he moved to the Division of Orthopaedic & Accident Surgery, where he commenced his research into osteoarthritic pain. Within the field of osteoarthritic pain, his specialities are primarily in two quite diverse areas; quantified histological change in the osteoarthritic knee and measurement of pain thresholds. He is currently investigating the change in an individual’s sensitivity to pain evoked by exercise.

In addition to his pain related research he specializes in the biology of bone repair, osteoarthritis and osteoporosis. Having recently been awarded a Technology Strategy Board – EPSRC grant to develop nano-enabled intranasal delivery of PTH (1-34) for the treatment of osteoporosis. Further information 

 

 annapiccinini
Dr Anna Piccinini
Anne McLaren Fellow, Faculty of Science

show/hide full profile...

Anna is an Anne McLaren Fellow at the School of Pharmacy in Nottingham. Her research has contributed to advances in the understanding of how endogenous inflammatory molecules that signal tissue damage also drive pathological inflammation during chronic joint inflammation in rheumatoid arthritis (Imperial College London 2008-2011; University of Oxford 2011-2015). Recently, Anna has uncovered a novel regulatory mechanism by which molecules of the extracellular matrix, the major component of the cellular microenvironment, influence immune cell behaviour and response to infection by regulating microRNA biogenesis and, thus, inflammatory gene expression.

Her research interests include: posttranscriptional regulation of inflammatory gene expression, regulation of microRNA biogenesis, expression and stability by the extracellular matrix, innate immune response to injury and infection and macrophage biology and function. Further information

  

Dr-Ryder-cropped
Dr Stephen Ryder
Director of Research and Innovation, Nottingham University Hospitals

show/hide full profile...

Since June 1994 Dr Ryder has been a consultant Physician in Hepatology and Gastroenterology at the Nottingham Digestive Diseases Centre and Biomedical Research Unit.

He became Director of Research and Innovation at Nottingham University Hospitals in April 2016.

His major clinical and research interest is hepatitis C infection and large clinical trials in hepatology. He was recognised as one of the leading recruiters to commercial clinical trials in the “NIHR at 10” awards.

Dr Ryder was the national lead for the Hepatology Clinical Research Network until 2015 and is the East Midlands lead for Division 6 of the CRN.

He is currently Hepatology Vice President of the British Society of Gastroenterology.

He graduated from Nottingham University Medical School and trained in hepatology at St Mary’s Hospital and Kings College Hospital London. Further information

   

Brigitte_MP250110AH2-_0137
Professor Brigitte Scammell
Professor in Orthopaedics, Faculty of Medicine & Health Science, Queen's Medical Centre

show/hide full profile...

Brigitte is a Consultant Orthopaedic Surgeon in adult foot and ankle surgery at The City Hospital, Nottingham and Professor of Orthopaedic Sciences at the University of Nottingham. She heads the Academic Orthopaedic Unit and is the Admissions Sub-Dean for the Faculty of Medicine. Her clinical interests are in adult orthopaedics, especially of the foot and ankle, with a particular emphasis on the reconstruction of severe deformity and treatment of infection in patients with diabetic foot disorders.

In 1996 she moved to the University of Nottingham as a Senior Lecturer. She became Head of the Division of Orthopaedic and Accident Surgery in 1999. Initially she concentrated on undergraduate education and went on to complete an MMedSci degree in clinical education at the university. She has dedicated much of her professional life to teaching and helping others realise their full potential, from medical students, supervision of BMedSci, DM and PhD students, to running Basic Science and Statistics courses for orthopaedic registrars. She was presented with a Lord Dearing Award in recognition of her teaching and learning excellence in 2004.

She is a founding member of the Arthritis Research UK Pain Centre which opened in Nottingham in 2010 with a £2.5m grant and of the Arthritis Research UK Sports, Exercise and Osteoarthritis Centre which started this year. In 2010 she was promoted to Professor, becoming the first woman in the UK to be a professor of orthopaedics. She is the Admissions Sub-Dean for the Faculty of Medicine and she continues to work for the NHS 50% of her time. Further information

  

Joanne Stocks_001-02
Dr Joanne Stocks
Translational Research Facilitator, Rheumatology, City Hospital

show/hide full profile...

Joanne currently is working on a number of projects including a collaboration with the OA Trial Bank to identify placebo responders and predictors of response to osteoarthritis treatment using individual patient data, and a clinical trial to investigate responders to topical treatments for painful knee osteoarthritis.

 

mikestocks  
Dr Michael Stocks
Pharmacy, University Park

show/hide full profile...

Michael is a synthetic medicinal chemist with a PhD in organic chemistry and has over 20 years' experience in Medicinal Chemistry in the pharmaceutical industry through his careers at Fisons’ Pharmaceuticals, Astra AB and then AstraZeneca. He has worked in most areas of medicinal chemistry concentrating recent efforts on GPCR-based drug discovery projects. In April 2012, he made the transition into academia and was appointed as Associate Professor of Medicinal Chemistry in the Division of Medicinal Chemistry and Structural Biology. His research interests centre on pre-clinical drug discovery and the investigation of novel drug delivery systems thus building on his expertise from working in the pharmaceutical industry designing novel, high quality drug-like chemical starting points to allow translational investigation of new biological mechanisms. Specific therapeutic target areas of interest are in GPCR-based drug discovery - for example designing novel antagonists of the chemokine CCR5 receptor for indications in HIV and oncology and using chemical biology methods to design and synthesise molecular probes to unravel cell signalling pathways in, for example, the challenging purinergic P2Y receptor area to enable initiation of new drug discovery projects in areas of un-met medical need.

His research interests also cover the design and synthesis of self-assembling pro-drugs of known therapeutic agents, for example TRPVI antagonists, that may well have a beneficial effect in the treatment of osteoarthritis pain. The research (in collaboration with Dr Maria Marlow from the Division of Drug Delivery & Tissue Engineering and Professor Victoria Chapman from the Arthritis UK pain centre) will look into a novel drug delivery approach to deliver TRPVI antagonists at a sustained localised concentration within the osteoarthritis joint thus avoiding the TRPVI on-target safety issues observed through systemic exposure. Further information 

 

B-Thomson 
Dr Brian Thomson
Consultant Physician and Clinical Academic, Faculty of Medicine & Health Sciences

show/hide full profile...

Brian's principal research interest is the pathogenesis of infection with human hepatitis viruses. Within this broad field, he is particularly interested in the relationship between chronic inflammatory change generated by viral infection and carcinogenesis. He is also engaged in using tissue engineering to develop models of human liver for use in studies of viral pathogenesis and other infectious and inflammatory diseases. Further information

 

 Ana-Valdes_2
Dr Ana Valdes 
Associate Professor and Reader, Medicine, City Hospital

show/hide full profile...

Ana Valdes is a genetic epidemiologist with extensive expertise in osteoarthritis and other complex diseases.  As part of her work in the European TREAT-OA consortium she has pioneered studies into the genetic factors that contribute to the pain experience in osteoarthritis patients. She is also studying the risk factors that influence  neuropathic pain like symptoms in osteoarthritis  patients and to persistent pain post total joint replacement. As part of a EULAR funded project grant she is currently investigating the genetic and epigenetic factors that contribute to these clinical traits. Understanding these components is key to unravel the discordance between structural disease and pain presence and severity in osteoarthritis and for advancing clinical management of osteoarthritis. Further information

  

kavita-vedhara-image 
Professor Kavita Vedhara 
Professor of Health Psychology, Medicine, Queen's Medical Centre

show/hide full profile...

Kavita is a health psychologist with expertise in experimental and applied research examining the diverse ways psychological factors influence health and disease outcomes and the development of psychological interventions to improve these outcomes. This research has included investigations into the effects of psychological interventions on disease activity in patients with rheumatoid arthritis; the placebo effect in pain and interventions to promote medication adherence. Further information 

 

DAW_PRP0251 
  Professor David Walsh
  Director, Arthritis Research UK Pain Centre, Honorary Consultant Rheumatologist

show/hide full profile...

David Walsh is Professor of Rheumatology at the University of Nottingham and Consultant Rheumatologist at Sherwood Forest Hospitals NHS Foundation Trust, where he directs the Back Pain Unit which provides diagnostic assessment and multidisciplinary Pain Management Programmes for people with chronic low back pain. In 2010 he established the Arthritis Research UK Pain Centre in Nottingham, together with a multidisciplinary research team including preclinical neurosciences, psychology, neuroimaging, orthopaedics and evidence synthesis. The Centre aims to develop new and improved treatments through a translational research programme into the mechanisms by which changes within the joint and in the nervous system interact with psychosocial factors to produce arthritis pain. His preclinical research has focused on structural changes that contribute to joint pain, in particular angiogenesis, nerve growth and inflammation in the synovium and subchondral bone. His clinical research is defining the spectrum of pain phenotypes in people with arthritis based on underlying pain mechanisms, in order to better target treatments to those most likely to benefit. Further information

 

Kirsty-Widdowson
Kirsty Widdowson
Patient and Public Involvement and Engagement Facilitator, Research and Innovation, NUH NHS Trust

show/hide full profile...

Kirsty graduated in 2010 with a BA (Hons) in Childhood Studies and has worked in research within the NHS over the last two years. Previously Kirsty worked for the Medicines for Children Research Network East as the Patient and Public Involvement lead, supporting paediatric PPI activities within the local network. In her role she developed a Young Persons Advisory Group (YPAG) which aims to support researchers in designing, developing and delivering effective research studies for children, young people and their families.

In 2015 Kirsty joined the Research and Innovation team as the Patient and Public Involvement and Engagement Facilitator, supporting the Arthritis Research UK Pain Centre’s PPI/E programme. Kirsty aims to ensure meaningful involvement with patients and the public throughout the design, development, delivery and dissemination of research studies and within the ARUK Pain Centre’s daily activities. Further information

 

Debbie-Wilson_DSC0002
Deborah Wilson
Specialist Nurse, Rheumatology Research, Kings Mill Hospital Sherwood Forest Hospital's NHS Foundation Trust

show/hide full profile...

Debbie is a Specialist research nurse working at Sherwood Forest Hospitals for 13 years.  She is a member of the Trust’s R&D committee and Clinical ethics committee, Coordinator of the Tissue repository at SFH and responsible for the consent process.  She is also Chair of the Trent ARENA meeting (a forum for nurse development and excellence).

 

SWoodhams
Dr Steve Woodhams 
Post-doctoral Researcher, School of Life Sciences

show/hide full profile...

Steve is a Research Fellow currently working on the link between anxiety and osteoarthritic pain in preclinical models of arthritis. Steve completed a Neuroscience MSci at the University of Nottingham and followed onto a PhD with
a focus on studying spinal cord mechanisms of pain. He then undertook a 5 year post-doctoral position at the Institute of Experimental Medicine in Budapest, Hungary, where he learned complementary anatomical techniques, including
super-resolution microscopy. Now back at the Arthritis Research UK Pain Centre, Steve is aiming to combine expertise in behavioural, physiological, and anatomical approaches to further study the intricate changes in central neuronal
circuitry which underlie arthritic chronic pain states. Further information

  

LWyatt-photo_Feb 2016
Dr Laura Wyatt
Research Fellow, Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis

show/hide full profile...

Laura is a Research Fellow in the Arthritis Research UK Centre for Sport, Exercise and Osteoarthritis (CSEO). Laura is currently a Principal Investigator on the Significant Ankle Ligament Injury (SALI) study in the CSEO. The SALI study seeks to identify the prevalence and risk factors for incomplete recovery of normal function and poor patient reports outcome measures following significant ankle injury.  In addition to identifying the incidence, and individual risk factors for the development of ankle OA following significant ankle injury.

Laura undertook her PhD within the Arthritis Research UK Pain Centre and graduated from the University of Nottingham in 2015.  Her thesis investigated structural associations of symptomatic knee osteoarthritis. Laura's research interests include causes of pain in osteoarthritis and risk factors for poor patient reported outcomes. Further information

  

Weiya-Zhang 
Professor Weiya Zhang 
Associate Professor & Reader in Musculoskeletal Epidemiology, Medicine, City Hospital campus

show/hide full profile...

Weiya qualified as a Bachelor of Medicine (BMed) and Bachelor of Public Health (BPH) 1978-1983, and Master of Epidemiology (MEpi) 1983-1986 from Sichuan University Medical School. He received his PhD in Evidence Based Medicine in 1997 from the University of Nottingham. He was jointly funded scholar by the Chinese Education Ministry and British council Technology Scheme and honorary research officer in the WHO MONICA Belfast 1991-1992, research fellow and course tutor 1997-2002 in Aston University, senior lecturer 2002-2005,associate professor 2005-2011 and reader from 2011 in the University of Nottingham.

Weiya is the head of the Evidence Based Medicine Group in the Arthritis Research UK Pain Centre. He has led the development of the European evidence based recommendations for osteoarthritis, gout and CPPD, and the Osteoarthritis Research Society International Treatment Guidelines. He is currently a member of the NICE osteoarthritis Clinical Guideline Development Committee, a member of the British Society of Rheumatology Gout Working Group, a member of the Arthritis Research UK Fellowship Implementation Committee, and a member of the Editorial board of Osteoarthritis & Cartilage. His current research areas include epidemiology, clinical trials and evidence based medicine in osteoarthritis and gout. Further information

 

Arthritis Research UK Pain Centre

Clinical Sciences Building
City Hospital
Nottingham, NG5 1PB

telephone: +44 (0) 115 823 1766 ext 31766
fax: +44 (0) 115 823 1757
email: paincentre@nottingham.ac.uk