Professor of Applied Biochemistry, Faculty of Science
Born: Wallasey, Wirral 2nd August 1955. Education: Wallasey Grammar and Marple Hall Grammar Schools; Pembroke College, Oxford (BA 1976; MA, 1980). Employment: Lister PostDoc, University of Bristol (81-82); Oppenheimer Postdoc, University of Cambridge (83-84); Supervisor (Queens College, Cambridge, 84); University of Nottingham (84-present). Visiting Professor: Institute für Organische Chemie und Makromolekulare Chemie, Friedrich Schiller Universität, Jena, Federal Republic of Germany (2009-2013). Awards: Royal Society of Chemistry Junior Medallist (1991); Oxford University DSc (2002); den Kongelige Norske Fortjenstorden (Ridder av 1. klasse) - the Royal Norwegian Order of Merit (RFOO), 2011.
Video of DSc award - November 2002; Video of Norwegian award; Wikipedia Norway list of people from Wirral
Steve has been a Director of the NCMH (National Centre for Macromolecular Hydrodynamics) - which he founded - for the last 27 years, a period which has seen hydrodynamic methods (analytical… read more
NIKOLAJSKI M, ADAMS GG, GILLIS RB, BESONG DT, ROWE AJ, HEINZE T and HARDING SE, 2014. Protein-like fully reversible tetramerisation and super-association of an aminocellulose. Nature: Scientific Reports. 4, 3861 GARCÍA DE LA TORRE, J. and HARDING, S.E., 2013. Hydrodynamic modelling of protein conformation in solution: ELLIPS and HYDRO Biophysical Reviews. 5, 195-206
BOWDEN, G.R., BALARESQUE, P., KING, T.E., HANSEN, Z., LEE, A.C., PERGL-WILSON, G., HURLEY, E., ROBERTS, S.J., WAITE, P., JESCH, J., JONES, A.L., THOMAS, M.G., HARDING, S.E. and JOBLING, M.A., 2008. Excavating past population structures by surname-based sampling: the genetic legacy of the Vikings in Northwest England Molecular Biology and Evolution. 25(2), 301-309
Steve has been a Director of the NCMH (National Centre for Macromolecular Hydrodynamics) - which he founded - for the last 27 years, a period which has seen hydrodynamic methods (analytical ultracentrifugation, light scattering, viscometry etc.) come from almost oblivion to flourish as tools for biomolecular characterisation. He has published nearly 390 research papers and books in the fields of Biomolecular Hydrodynamics and Applied Biochemistry: his Research web pages are on http://www.nottingham.ac.uk/-sczsteve/research.htm. Much of the work has involved international collaboration with groups in Norway, the USA, Germany, Spain, Russia and Australia. In 2010 he gave the annual Pfizer lecture at the University of Connecticut and in 2011 he was awarded den Kongelige Norske Fortjenstorden (Ridder, 1. klasse) - the Royal Norwegian Order of Merit (RFOO) - by King Harald of Norway.
Hydrodynamics: His main focus is on the size, shape and interactions involving large molecules of molecular weight >1000 - "macromolecules" - in solution: developing, improving and applying the methodology. Recent research highlights include the development of improved methods of getting molecular weight distributions (view), conformation (view), interactions (view), the discovery of some sugars that behave like proteins (view & view), designing macromolecular blocks against gluten intolerance (view - "the most viewed article in BMC Biophysics") and the nature and stability of carbohydrate vaccines (view & view). A new 3-year study starts Dec 2014 (funded by BBSRC Diet & Health Research Industry Club - DRINC) on beta-glucan interactions responsible for cholesterol lowering. DNA: His other focus is on DNA - the molecule of life: trained by the man who discovered hydrogen bonds in DNA (view), he has been a key part of the team researching Y-chromosome DNA & the Scandinavian settlements of Britain (view & view).
Support: Steve is grateful to the Royal Society, BBSRC, EPSRC, Wellcome Trust, GSK Vaccines; Medimmune; Factor H Group/Inovo and Kelloggs for their generous support. Books: Stephen Hardings Amazon.co.uk page and Amazon.com page; Collection of research lectures: Steve's series of 10 lectures from the Friedrich-Schiller Universität, Jena.