Professor David A Walker

Contact Details

Membership Status

Full Member

Institute Research Section

Research Interests

1. Children’s Brain Tumour Research Centre (CBTRC) - neuro-oncology clinical trials, health outcomes during neuro-rehabilitation in children and young people, impact of cerebellar injury on outcome, CNS targeting of cancer treatments.
2. Cancer in Growth and Development – role of apoptosis in cerebellar tumour development, impact of ontogeny of tissue growth factors and proteins on tumour growth during infancy, childhood and adolescence.
3. Clinical trials of new treatments in childhood cancer and leukaemia with a particular interest in nervous system tumours – Primitive Neuro-Ectodermal Tumours / medulloblastoma, Low Grade Glioma, Brain Stem Glioma and High Grade Glioma, CNS Germ Cell Tumours.

Research Techniques

1. Clinical trials in childhood and adolescence – design and conduct
2. Application of health outcome measures in childhood and adolescence

Recent Publications

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Scotting PJ, Walker DA & Perilongo G (2005) Childhood solid tumours: a developmental disorder. Nature Reviews 5, 481-487

Walker DA, Wilne S (2005) Treatment of medulloblastoma in young children. Lancet Oncology 6, 541-542

Taylor RE, Bailey CC, Robinson KJ, Weston CL, Walker DA, Ellison D, Ironside J, Pizer BL, Lashford LL (2005) on behalf of the United Kingdom Children’s Cancer Study Group (UKCCSG) Brain Tumour Committee. Outcome for patients with metastatic (M2-3) medulloblastoma treated with SIOP/UKCCSG PNET-3 chemotherapy. European Journal of Cancer 41, 727-734

Hyatt M, Gopalakrishnan G, Bispham J, Gentili JS, McMillen IC, Rhind SN, Rae MT, Kyle CN, Brooks AN, Jones C, Budge H, Walker D, Stephenson T, Symonds ME (2006) Maternal nutrient restriction in early pregnancy programmes hepatic expression of GHR, PRLR, IGF-IIR, HGF, Bax and SOCS-3 and liver size in the adult male. Journal of Endocrinology (In press)

Teaching Responsibilities

• Special Study Module Paediatric Oncology 5th year Medicine
• Post graduate medical and nursing teaching and training

Funding

CRUK: “Translational study for children & adolescents with low grade glioma (TRANSCAL)”. £135,000. 1.12.06 - 48 months

Samantha Dickson Brain Tumour Trust: “Pathways II – Introduction of guidance to shorten symptom interval and enhance access to diagnostic pathways for CNS tumours in children & young adults, and evaluation by prospective observational cohort study”. £44,479. 1.9.06 – 12 months

CRUK: “SIOP-LGG 2003: Co-operative multi-centre study for children & adolescents with LGG”. £1365,845. 1.6.05 – 60 months

Students Supervised

Hannah Levis 2008
Emma Davis

Internal & External Responsibilities

1. Member - Brain Tumour Trials Committee, Société Internationale Oncologie Pediatrique (SIOP) 1993–
2. Co-Chairman Low Grade Glioma International Consortium (International Trial of Low Grade Glioma of Childhood 1995-
3. Chairman Astrocytic Tumour sub Committee of UKCCSG Brain Tumour Working Party 1998
4. Member of Scientific Advisory Board for Samantha Dickinson Trust (National brain tumour research charity) 2000-
5. Member scientific advisory committee 2002 International Symposium Paediatric Neuoroncology, London. This conference was sponsored by University of Nottingham CBTRC