Immunity and the Immune System
This 10 credit module provides an overview of the mechanisms and concepts underpinning the science of immunology.
Molecular Basis of Cancer
This 20 credit module is made up of a series of lectures giving students an in-depth understanding of normal cell regulatory mechanisms and how these are altered during the carcinogenic process.
This 10 credit module gives an overview of immunological approaches to cancer immunotherapy and immunological mechanisms and how these may be used to optimise therapeutic approaches.
This 20 credit module is made up of a series of lectures and discussion groups providing information on cancer vaccines. Topics include: what makes a good vaccine; different vaccine designs; animal models and immunological techniques. This module will cover subjects that have been introduced on the tumour immunology module in more depth.
Scientific Writing and Business Development
The 20 credit module focuses on the commercialism of research with lectures also on intellectual property. Invited speakers from industry will contribute to this module. In addition, students will learn how to write a business plan on a cancer immunotherapy concept. Students will work in groups to represent individuals in a company and they will develop their own novel concept and write a business plan.
This 20 credit module will provide information on the generation of monoclonal antibodies, clinical trials involving antibodies and the future uses of antibody therapy in cancer prevention.
This 20 credit module will highlight the current understanding of the immunobiology of tumours. This will include the following topics: immunosurveillance, tumour resistance, regulatory T cells. antigenic targets, cytokine therapy, non-specific immunity and animal models.
The research project is worth 60 credits. It will be undertaken on a tumour immunology related subject and will allow the student to learn the practical and intellectual skills necessary for scientific investigation. The student will also gain experience in project management and acquire more specialised skills related to the project. Students may be able to perform their projects in industrial placements. The module is assessed on progress reports (practical skills), an oral presentation and a write-up in the style of a scientific paper.
Examples of previous research projects
- Production of a monoclonal antibody that kills ovarian cancer cells
- An anti-endothelial vaccine targeting endothelin receptor B
- Modulation of vascular endothelial growth factor (VEGF) receptor signalling on human dendritic cells to improve anti-cancer immune responses
- Generation of recombinant ligand Fc fusion proteins to co-stimulate CD55 on T cells
- Microencapsulation of Hepatitis B surface antigen protein and DNA using supercritical fluid technology
- Perturbation of MAPK signalling pathways following exposure of dendritic cells to melanoma lysates
- Identification of antigen specific T regulatory epitopes
- Regulation of IL12, IL23 & IL27 gene expression in dendritic cells by malignant melanoma
- Interleukin (IL)- 27 modifies CD28 and CD55 mediated costimulation of naïve CD4+ T cells
- Tumour-mediated regulation of dendritic cell interaction with lymphendothelium
- Investigation of the effect of IL17 on MMP2 & 9 in breast cancer
- Antigen specific generation of Tr1
- Immune responses to tumour associated antigens in cancer
- The role of CD55 in mouse colorectal cancer
- Analysis of the tumour suppressor LIMD1 in breast cancer
- Investigation of encapsulated tetanus toxoid antigen to generate a single-dose vaccine to tetanus
For more details on our modules, please see the module catalogue.
The modules we offer are inspired by the research interests of our staff and as a result may change for reasons of, for example, research developments or legislation changes. This list is an example of typical modules we offer, not a definitive list.