Triangle

Course overview

Learn how to identify and develop targeted treatments for some of the world’s most challenging diseases. You will learn about key aspects of the drug discovery journey, from target identification, through drug synthesis and biological evaluation, all the way to considering intellectual property and clinical treatment.

Accredited by the RSC

This course is accredited by the Royal Society of Chemistry.

This represents a mark of quality for prospective students and for future employers. When you choose an RSC accredited chemistry programme, you can be confident that you are getting a high-quality education, providing the knowledge and key skills you need for a successful future.

Multidisciplinary expertise

You will be taught by experts from both the School of Pharmacy and the School of Life Sciences

Together with colleagues from the Faculty of Medicine and Health Sciences, the School of Pharmacy are joint 1st in the UK on Research Environment in the Research Excellence Framework 2021.

Research from both schools is transforming the lives of millions of people across the globe. Some of our recent contributions include:

  • developing an innovative materials discovery platform, leading to improved biomedical devices that reduce infection and improve healing
  • helping the NHS save £500m through research into the expansion of pharmacy services in England
  • influencing government policy internationally to establish community pharmacies as vaccination centres for influenza and COVID-19

Joint collaboration

You will establish practical and professional skills from both the School of Pharmacy and the School of Life Sciences. You will learn to communicate complex ideas through a variety of formats, such as a simulated pitch to investors for funding. You will develop core practical skills in key areas that underpin drug discovery, such as synthesis of drugs, and in vitro and in vivo analysis.

Local and global pharmaceutical links

Benefit from a range of teaching approaches from experts collaborating the pharmaceutical industry. The Schools have extensive links with local and global pharmaceutical organisations, including Sygnature Discovery, Excellerate Bioscience and GlaxoSmithKline.

Excellence in Teaching and Student Support

Members of our course team have won awards for excellence in teaching and student support. Our small group learning environment can help you settle in quickly and form a lasting network of connections.

A dedicated supervisor will support you during your research project. You will work alongside our researchers who are transforming lives and improving societies.

Examples of previous research projects include:

  • Computational chemistry - Identification of Potential Inhibitors against Factor XII related to COVID-19 using Molecular Docking
  • Synthetic organic/medicinal chemistry - Facile synthetic approaches to CGP-12177 analogues for exploring the β1-adrenoceptor secondary conformation
  • In silico pharmacokinetics - Evaluation of the impact of CYP2C8 polymorphisms on the efficacy and disposition of amodiaquine using physiologically based pharmacokinetic modelling
  • Drug screening - Characterization of RO7297590 binding properties to human cannabinoid CB1 and CB2 receptors using homogenous time-resolved fluorescence (HTRF)
  • Target identification - Targeting protease inhibitors to the gut-associated lymphoid tissues for improved treatment of HIV/AIDS

Listen to our masters drug discovery alumna, Rhianna explain why she chose this course and how the small group learning helped her reinforce her studies.

Why choose this course?

Accredited

by the Royal Society of Chemistry.

Top 5

A world top 5 university for pharmacy and pharmacology

QS World University Rankings by Subject 2022 and 2021

Academic expertise

from both the School of Pharmacy and the School of Life Sciences.

Honorary Professors

and guest industrial speakers present throughout the year.

Joint 4th place

in the UK for our research quality with our colleagues from the Faculty of Medicine and Health Sciences.

in the 2021 Research Excellence Framework

Joint 1st place

in the UK for our research environment with our colleagues from the Faculty of Medicine and Health Sciences.

in the 2021 Research Excellence Framework

Course content

You will learn about:

  • the historical and modern-day drug discovery process
  • computational approaches relevant to drug discovery
  • organic/medicinal chemistry relating to currently marketed drugs
  • Drug Metabolism and Pharmacokinetics (DMPK)
  • clinical usage of current drugs
  • pharmacotherapy of major human diseases and disorders
  • an understanding of disease biology and how it impacts upon human health
  • an understanding of how and why drugs fail or succeed in the drug discovery process
  • apply solutions to practical problems in medicinal chemistry, pharmacology, and drug discovery

Modules

Core modules

Principles of Drug Discovery 20 credits

This autumn semester module is supported by weekly chemistry workshops covering key concepts such as physicochemical properties, ADME, and drug-target interactions. Themes include:

  • The Drug Discovery Process
  • Target Identification and Validation
  • Hit and Lead Identification
  • Screening Compound Libraries
Drug Targets and Pharmacodynamics 20 credits

This autumn semester module introduces the major molecular targets of clinically used drugs and explores the pharmacodynamic basis of therapeutics used to treat major diseases and disorders. Themes include:

  • Quantitation of Drug Effects
  • The Diversity of Molecular Drug Targets
  • Cell Signalling Modalities and Their Relationship with Tissue and Organismal Behaviours
  • Pharmacotherapy of Major Human Diseases and Disorders
Drug Discovery and Development 20 credits

This spring semester module puts the Principles of Drug Discovery into practice. Themes include:

  • Synthetic Toolkit
  • Drug-Target Interactions and the Pharmacophore
  • Lead Optimisation
  • Developing a Drug from an Optimised Lead
  • Case studies of successful drugs

Students will also complete coursework including a semester-long group project and interpretation of real chemical patents.

Drug Metabolism and Pharmacokinetics 20 credits

This spring semester module explores the relationship between drug plasma concentrations and efficacy through the study of pharmacokinetics and drug metabolism. Themes include:

  • The key organs in the body influencing drug pharmacokinetics
  • The influence of pharmacokinetics in the drug discovery process
  • In-vitro and in-vivo methods available for quantitative pharmacokinetics
  • Compartmental and non-compartmental approaches to estimating pharmacokinetic parameters
  • The prediction of human pharmacokinetic parameters and simulation of plasma concentration- time profiles
  • The role of the Regulatory Authorities in drug development
Practical Drug Discovery 40 credits

This module spans both the autumn and spring semesters and provides first-hand research experience and insights into practical drug discovery including in the areas of:

  • Computational chemistry
  • Synthetic organic chemistry
  • Analytical chemistry
  • Quantitative pharmacodynamics
  • Quantitative pharmacokinetics
Individual Research Project 60 credits

In this summer semester module, student will experience an extended period working as part of an existing research group in either the School of Pharmacy or the School of Life Sciences. Students will present their work in the form of a dissertation, as well as through a poster presentation.

Examples of previous research projects include:

  • Development of electroceuticals for treating cancer
  • Synthesis of new P2Y2 receptor antagonists
  • DMPK assessment of Toll-like receptor 2 agonists and their prodrugs for mesenteric lymph nodes targeting to improve treatment of gastrointestinal cancer and HIV
  • Macromolecular drug conjugates for enhanced imaging and therapy
  • Establishing a nanoBRET assay for the multidrug pump ABCG2
  • Prediction of propylene glycol CNS concentration in the neonatal brain using PBPK modelling
  • Computational modelling of mu-opioid receptors during development of opioid tolerance
The above is a sample of the typical modules we offer but is not intended to be construed and/or relied upon as a definitive list of the modules that will be available in any given year. Modules (including methods of assessment) may change or be updated, or modules may be cancelled, over the duration of the course due to a number of reasons such as curriculum developments or staffing changes. Please refer to the module catalogue for information on available modules. This content was last updated on Thursday 27 July 2023.

Learning and assessment

How you will learn

  • Lectures
  • Workshops
  • Seminars
  • Lab sessions
  • Past papers
  • eLearning

Core modules are typically delivered by professors, associate and assistant professors. Our extensive links with the pharmaceutical industry mean we can offer a selection of lectures and workshops which are delivered by external speakers, with field-leading expertise in the area. Some practical laboratory sessions and research projects may be supported by postgraduate research students or postdoctoral research fellows.

We use Moodle, an e-learning package for the core parts of the course. For interactive sessions we use in-class polling platforms e.g. Socrative. We supplement face-to-face teaching with innovative assessment methods.

For the individual research project you will complete a report in the style of a scientific publication and discuss your research in a short viva. You will present your research in the form of a scientific poster.

How you will be assessed

  • Written exam
  • Oral exam
  • Poster presentation
  • Essay
  • Coursework
  • Online workbook
  • Online exams

Assessments will vary in number and styles across each module being studied.

Contact time and study hours

As a guide, one credit equals approximately 10 hours of work. For the taught-stage of the course, you will spend approximately a third of your time (around 400 hours) in lectures, tutorials, workshops, practical classes, including the directed study which is necessary in preparation for workshops/practical classes. Our class sizes stand at approximately 30. The remaining time will be completed as independent study. Tutorial sessions are built into the timetable and there are several group and individual meetings timetabled throughout the year. We hold six tutor meetings throughout the year. Additional meetings can be requested as needed.

The individual research project stage has an initial period of training. You will need to complete several assessment components for the module. There will be an element of independent research. Efficient time management during the project period is essential. For this course, the individual research project represents one third of the entire course (60 credits or approximately 600 hours). We hold a minimum of five formal meetings with your research supervisor throughout the duration of your project.

Entry requirements

All candidates are considered on an individual basis and we accept a broad range of qualifications. The entrance requirements below apply to 2024 entry.

Undergraduate degree2:1 related to biology or chemistry including (but not restricted to) pharmacy, pharmacology, biochemistry, genetics, life sciences, natural sciences, biomedical sciences

Applying

Our step-by-step guide covers everything you need to know about applying.

How to apply
Pharmacy laboratories

Where you will learn

Pharmacy laboratories

Improve your practical skills in some of the many research areas:

  • a molecular biology laboratory
  • computational chemistry laboratory
  • quarantine cell culture facility
  • an automated stem cell culture platform
  • synthetic organic chemistry laboratories

 

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Where you will learn

University Park Campus

University Park Campus covers 300 acres, with green spaces, wildlife, period buildings and modern facilities. It is one of the UK's most beautiful and sustainable campuses, winning a national Green Flag award every year since 2003.

Most schools and departments are based here. You will have access to libraries, shops, cafes, the Students’ Union, sports village and a health centre.

You can walk or cycle around campus. Free hopper buses connect you to our other campuses. Nottingham city centre is 15 minutes away by public bus or tram.

Fees

Qualification MSc
Home / UK £14,700
International £30,200

Additional information for international students

If you are a student from the EU, EEA or Switzerland, you may be asked to complete a fee status questionnaire and your answers will be assessed using guidance issued by the UK Council for International Student Affairs (UKCISA) .

These fees are for full-time study. If you are studying part-time, you will be charged a proportion of this fee each year (subject to inflation).

Additional costs

All students will need at least one device to approve security access requests via Multi-Factor Authentication (MFA). We also recommend students have a suitable laptop to work both on and off-campus. For more information, please check the equipment advice.

As a student on this course, we do not anticipate any extra significant costs, alongside your tuition fees and living expenses.

Funding

There are many ways to fund your postgraduate course, from scholarships to government loans.

We also offer a range of international masters scholarships for high-achieving international scholars who can put their Nottingham degree to great use in their careers.

Check our guide to find out more about funding your postgraduate degree.

Postgraduate funding

Careers

We offer individual careers support for all postgraduate students.

Expert staff can help you research career options and job vacancies, build your CV or résumé, develop your interview skills and meet employers.

Each year 1,100 employers advertise graduate jobs and internships through our online vacancy service. We host regular careers fairs, including specialist fairs for different sectors.

International students who complete an eligible degree programme in the UK on a student visa can apply to stay and work in the UK after their course under the Graduate immigration route. Eligible courses at the University of Nottingham include bachelors, masters and research degrees, and PGCE courses.

Graduate destinations

We have seen a number of alumni progress into a range of scientific careers, particularly in pharmaceutical industry, academia, other related industries (e.g. scientific writing) or have continued their studies by starting a PhD.

Both Schools work and collaborate with strong industrial links, such as Sygnature Discovery Ltd and GlaxoSmithKline. We have hosted guest lectures with these companies providing an industrial insight to further enhance student's employability. 

Career progression

86% of postgraduate taught students from the Faculty of Science secured graduate level employment or further study within 15 months of graduation. The average annual salary for these graduates was £25,985.*

*HESA Graduate Outcomes 2019/20 data published in 2022. The Graduate Outcomes % is derived using The Guardian University Guide methodology. The average annual salary is based on data from graduates who completed a full-time postgraduate taught degree with home fee status and are working full-time within the UK.

Royal Society of Chemistry

This course is accredited by the Royal Society of Chemistry.

Two masters graduates proudly holding their certificates
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Dr Shailesh Mistry

Assistant Professor of Medicinal Chemistry and Course Director

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This content was last updated on Thursday 27 July 2023. Every effort has been made to ensure that this information is accurate, but changes are likely to occur given the interval between the date of publishing and course start date. It is therefore very important to check this website for any updates before you apply.