C93IIS Immunity and the Immune System
This 10 credit module provides an overview of the mechanisms and concepts underpinning the science of Immunology and Allergy.
A34C01 Molecular Basis of Cancer
This 20 credit module is made up of a series of lectures giving students an in-depth understanding of normal cell regulatory mechanisms and how these are altered during the carcinogenic process.
This module includes:
- DNA structure and function
- Oncogenes and tumour suppressor genes
- Molecular biology of the cell cycle
- Chromosome abnormalities in human cancer
- Familial cancer syndromes.
A34C12 Tumour Immunology
This 10 credit module gives an overview of immunological approaches to cancer immunotherapy and immunological mechanisms and how these may be used to optimise therapeutic approaches.
- Anti-tumour Antibody Responses
- Cellular Anti-tumour Immunity
- Natural Killer Cells
- CAR and redirected T Cell therapies
- Cytokine Therapy
- Immune evasion by tumours
CI4CV1 Cancer Immunotherapy
This 20 credit module is made up of a series of lectures and discussion groups providing information on cancer vaccines. Topics include: what makes a good vaccine; different vaccine designs; animal models and immunological techniques. This module will cover subjects that have been introduced on the tumour immunology module in more depth.
CI4SB2 Scientific writing and business development
The 20 credit module focuses on the commercialism of research with lectures also on intellectual property. Invited speakers from industry will contribute to this module. In addition, students will learn how to write a business plan on a cancer immunotherapy concept. Students will work in groups to represent individuals in a company and they will develop their own novel concept and write a business plan.
CI4MA3 Monoclonal antibodies
This 20 credit module will provide information on the generation of monoclonal antibodies, clinical trials involving antibodies and the future uses of antibody therapy in cancer prevention.
CI4HT4 Host Tumour Interface
This 20 credit module will highlight the current understanding of the immunobiology of tumours. This will include the following topics: immunosurveillance, tumour resistance, regulatory T cells. antigenic targets, cytokine therapy, non-specific immunity and animal models.
A34C10 Cancer Statistics and Epidemiology
The aim of this 10 credit module is to give students an understanding of the principles underlying the design and analysis of epidemiological studies and clinical trials. Topics will include: study design, bias and confounding, sampling variation, summarising and presenting data, measures of effect, hypothesis testing (t-test, chi-squared test), survival and longitudinal data, meta-analysis, non-parametric methods, correlation, introduction to multivariate regression analysis, screening, sample size and power.
Students will have the ability to use a range of routinely available statistical sources for clinical research, and to describe and explain concepts fundamental to clinical research of all kinds. They will be able to describe, interpret and appraise the applicability of statistical methods used in a wide range of clinical and biological research.
This module is assessed by a 1500-2000 report (30%) and a one and a half hour exam consisting of multiple-choice and short answer questions (70%).
A34MO4 MSc Research Project
The research project is worth 60 credits. It will be undertaken on a tumour immunology related subject and will allow the student to learn the practical and intellectual skills necessary for scientific investigation. The student will also gain experience in project management and acquire more specialised skills related to the project. Students may be able to perform their projects in industrial placements. The module is assessed on progress reports (practical skills), an oral presentation and a write-up in the style of a scientific paper.
Examples of previous research projects:
- Production of a monoclonal antibody that kills ovarian cancer cells
- An anti-endothelial vaccine targeting endothelin receptor B
- Modulation of vascular endothelial growth factor (VEGF) receptor signalling on human dendritic cells to improve anti-cancer immune responses
- Generation of recombinant ligand Fc fusion proteins to co-stimulate CD55 on T cells
- Microencapsulation of Hepatitis B surface antigen protein and DNA using supercritical fluid technology
- Perturbation of MAPK signalling pathways following exposure of dendritic cells to melanoma lysates
- Identification of antigen specific T regulatory epitopes
- Regulation of IL12, IL23 & IL27 gene expression in dendritic cells by malignant melanoma
- Interleukin (IL)- 27 modifies CD28 and CD55 mediated costimulation of naïve CD4+ T cells
- Tumour-mediated regulation of dendritic cell interaction with lymphendothelium
- Investigation of the effect of IL17 on MMP2 & 9 in breast cancer
- Antigen specific generation of Tr1
- Immune responses to tumour associated antigens in cancer
- The role of CD55 in mouse colorectal cancer
- Analysis of the tumour suppressor LIMD1 in breast cancer
- Investigation of encapsulated tetanus toxoid antigen to generate a single-dose vaccine to tetanus
More Details about all the modules.
The above is a sample of the typical modules that we offer but is not intended to be construed and/or relied upon as a definitive list of the modules that will be available in any given year. Due to the passage of time between commencement of the course and subsequent years of the course, modules may change due to developments in the curriculum and information is provided for indicative purposes only.