Genetics BSc

This module combines lectures and laboratory classes and introduces you to the structure and function of significant molecules in cells, and the important metabolic processes which occur inside them. You will study, amongst other topics, protein and enzyme structure and function, the biosynthesis of cell components, and the role of cell membranes in barrier and transport processes. You'll examine how information in DNA is used to determine the structure of gene products. Topics include DNA structure, transcription and translation and mutation and recombinant DNA technology.

Through lectures, workshops and tutorials this module will enable you to develop core skills in scientific writing, data handling and analysis, experimental design and scientific presentations. This module is designed to develop your problem solving scientific skills. An important aspect of this module is the small-group tutorials which allow you to get to know the member of staff who will be your tutor for the duration of your studies.

Life on Earth provides an introduction to the fundamental characteristics and properties of the myriad of organisms which inhabit our planet, from viruses, bacteria and Archaea, to plants and animals. In weekly lectures, and regular laboratory practical classes, you will consider how living organisms are classified, how they are related genetically and phylogenetically, and basic aspects of their structure and function.

Starting with Darwin’s theory of evolution, you will learn how natural selection and other evolutionary forces have shaped the ways in which organisms interact with each other and their environment. In addition to lectures, practical classes will give you hands-on experience with a range of ecological and behavioural concepts in the laboratory and the field.

In this module, you will be introduced to the physiology of major systems such as cardiovascular, nervous, and musculoskeletal, including some aspects of drug action. This module will allow you to understand your biochemical and genetics knowledge in the context of the intact organism. This module includes lectures and laboratory classes.

This module will give you a good grounding in the basic principles of the nervous system of humans and other animals. Topics will include neuroanatomy, cellular neuroscience, neuropharmacology, sensory systems, neuroendocrinology, memory, behavioural neuroscience and diseases of the nervous system. These will be delivered through weekly lectures and practical classes.

Molecular events that occur during the control of gene expression in bacteria will be explored. You'll learn by considering case studies, which will show you how complex programmes of gene action can occur in response to environmental stimuli. You will also study the regulation of genes in pathogenic bacteria.

Introduces key evolutionary concepts and their application in the animal kingdom. Areas you will study include the history of evolutionary thinking, natural selection versus the neutral theory, sexual selection and human evolution. 

A comprehensive introduction to the study of animal behaviour, from the physiological and genetic bases of behaviour to its development through learning and its adaptive significance in the natural environment. Through practical classes, you will learn about the physiological basis of fundamental behaviours. Using examples from across the animal kingdom, you will learn how predictive modelling, experimental and observational approaches integrate to explain how and why animals behave as they do.

Examines the basic concepts of vertebrate embryonic development. You will discuss specific topics including germ cells, blood and muscle cell differentiation, left-right asymmetry and miRNAs. The teaching for this module is delivered through lectures. 

Through practical sessions, you will learn the techniques of biological image production and manipulation, including the ability to generate biological images of the highest technical quality and scientific value. You will build an understanding of the principles behind photography and how to get the most out of state of the art photographic and imaging equipment.

Studying this module, you'll be able to explain how the nervous system develops, is organised, and processes information. This will be achieved through presentation of comparative invertebrate and vertebrate studies, consideration of evolutionary concepts, and a detailed analysis of the development, structure, and function of the mammalian brain. The lecture sessions are complemented by workshops on Drosophila and chick embryo development, on the neuroanatomy of the human spinal cord, and dissection of pig brains subject to the availability of tissue.

You'll cover the key groups of eukaryotic and prokaryotic microorganisms relevant to microbial biotechnology, principles of GM, and strain improvement in prokaryotes and eukaryotes. The impact of “omics”, systems biology, synthetic biology and effects of stress on industrial microorganisms are explored, alongside the activities of key microorganisms that we exploit for biotechnology.

You will learn about the forces determining the distribution and abundance of species and be able to use models to predict the dynamics of populations under a range of conditions. You will recognise how interactions between species can drive co-evolutionary processes leading to an understanding of the organisation of natural systems working systematically from populations through to communities, ecosystems and biogeographical scales.

This module will provide you with an understanding of the mechanisms behind electrical conduction in neurones. You will learn about the generation of the membrane potential and its essential role in signaling within the nervous system. You will develop an appreciation of the role of ion channels in the generation of trans-membrane currents and how myelin can accelerate signal conduction. You will also learn about the important supporting roles that astrocytes and glial cells play in the nervous system in order to ensure its efficient functioning.

This module will provide an in-depth analysis of drug action, and its application to the design and use of current therapeutics. You will learn to define what drugs are, the different ways they act at the cellular and molecular level, and the pharmacokinetic principles underlying drug absorption, distribution, metabolism and elimination. You will explore examples in cardiovascular and respiratory disease, diabetes and obesity, CNS disorders, cancer and infectious disease. Overall, you will develop a deep understanding of what the discipline of pharmacology represents, and its application to both basic biological research and current and future medical advances.

This module studies transporters and channels, groups of proteins responsible for controlling the flow of substances across lipid bilayers that are critical for cellular homeostasis. You will learn the basics of transporter and channel biology, and then apply this knowledge to design virtual experiments, the simulated results of which would gradually reveal the molecular basis of a transporter or channel related disease. You will design a series of “virtual experiments”, with appropriate controls, in order to probe the function of a particular gene in a physiological condition.

This module will teach you the underlying neurophysiology and pathology associated with several common CNS disorders and the neuropharmacology of currently available medication. You will learn about the neurotransmitters and pathways involved in normal brain function and how changes in these contribute to abnormal function. You will also decipher the pharmacological mechanisms of drugs used to treat these CNS disorders. You will cover numerous human diseases including those with great significance such as Alzheimer's disease, epilepsy, schizophrenia and autism.

This module will provide you with a comprehensive understanding of the structures of DNA and RNA and how the information within these nucleic acids is maintained and expressed in both prokaryotic and eukaryotic cell types. Additionally, this module describes how nucleic acids can be manipulated in vitro using molecular biological approaches. Practical classes will focus your learning on the cloning and manipulation of DNA to express recombinant proteins in bacterial systems.

The project is a year-long level three module. You will undertake detailed research on a chosen topic after discussion with a supervisor. Each project will involve collection of data by means such as experiment, questionnaire or observation, as well as the analysis and interpretation of the data in the context of previous work.

Examines the mechanisms through which eukaryotic genes are expressed and regulated, with emphasis placed on recent research on transcriptional control in yeast and post-transcriptional control in eukaryotes. Studying this module will include having three hours of lectures per week.

Consider the genetic effects of reduced population size, especially relating to the conservation of endangered species. You will study topics including genetic drift and inbreeding in depth, from theoretical and practical standpoints. You will spend around one and a half hours per week in lectures studying this module, plus a two and a half hour computer practical.

Examine the molecular causes of the ageing and malignant transformations of somatic cells that are observed during a single lifespan, and gain an understanding of the necessity to maintain the genome intact from one generation to the next. Around three hours per week will be spent within lectures studying this module.

This module gives a detailed understanding of the genetics and biochemistry behind the properties of parasites and microorganisms that cause major human diseases in the present day. You will have a three-hour lecture once per week for this module.

During this module you will examine the ways in which DNA and protein sequences are used to investigate evolutionary relationships among organisms. You will study topics including the techniques of sequence comparison and the construction of evolutionary trees. You will spend three hours of lectures per week plus a total of two three-hour practicals in this module.

You will consider the molecular mechanisms underlying stem cell function during embryogenesis and adulthood. This will involve studies of regeneration and repair of tissues and pluripotency. You will have one two-hour lecture per week in this module. 

Examines genetic variation in humans, including variation at the DNA level, and the study of human population history using genetic methods. Around three hours per week will be spent within lectures studying this module.

This module will explore the interactions between science and society through a series of lectures, discussion groups and workshops. Topics that will be explored include the ethical parameters that govern how scientific work is constrained, ways in which scientific discoveries can/should be disseminated to the wider community, the wider responsibilities that follow the acquisition of new knowledge and the concept of ‘citizen science’, where science takes place outside the traditional academic centres of work. This mode consists of a three-hour lecture incorporating discussion groups once per week.